16265-11-5

Basic information

• Product Name: 4-Bromo-2-methylimidazole
• Synonyms: 4-BROMO-2-METHYLIMIDAZOLE;4-Bromo-2-methyl-1H-imidazole;4-Bromo-2-methyl-1H-imidazole 98%;2-Methyl-4-bromo-1H-imidazole;5-BroMo-2-Methyl-1H-iMidazole
• CAS NO: 16265-11-5
• Molecular Formula: C₄H₅BrN₂
• Molecular Weight: 161
• Product Categories: blocks;Bromides;Imidazoles;Imidazol&Benzimidazole;Imidaxoles
• Mol File: 16265-11-5.mol

Chemical Properties

• Melting Point: 158-160°C
• Boiling Point: 333.9°Cat760mmHg
• Flash Point: 155.7°C
• Appearance: /
• Density: 1.723g/cm³
• Vapor Pressure: 0.000257mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Keep Cold
• PKA: 12.26±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-2-methylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-methylimidazole(16265-11-5)
• EPA Substance Registry System: 4-Bromo-2-methylimidazole(16265-11-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 16265-11-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Bromo-2-methylimidazole is utilized as a key intermediate in organic synthesis for the creation of a variety of compounds. Its reactivity allows for the formation of new chemical entities that can be tailored for specific applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Bromo-2-methylimidazole is employed as a building block for the development of new drugs. Its unique structure and properties make it suitable for the synthesis of compounds with potential therapeutic effects.
Used in Agrochemical Production:
4-Bromo-2-methylimidazole is also used in the production of agrochemicals, where it serves as a precursor for the synthesis of compounds that can be used in agriculture to protect crops from pests and diseases.
Used in Dye Manufacturing:
4-Bromo-2-methylimidazole is utilized in the manufacturing of dyes, where its chemical properties contribute to the color and stability of the final product.
Used in Specialty Chemicals Production:
4-Bromo-2-methylimidazole finds application in the production of specialty chemicals, where its unique characteristics are harnessed to create high-value products for specific industries.

InChI:InChI=1/C4H5BrN2/c1-3-6-2-4(5)7-3/h2H,1H3,(H,6,7)

Upstream product

• 4002-81-7 4,5-Dibromo-2-methylimidazole 
• 693-98-1 2-methylimidazole 

Downstream Products

• 24134-09-6 5-bromo-1,2-dimethyl-1H-imidazole 
• 13739-48-5 2-methyl-4-phenyl-1H-imidazole 
• 850429-59-3 4-bromo-1,2-dimethyl-1H-imidazole 
• 1135683-20-3 C₁₂H₁₁BrN₂O₃ 

Relevant articles and documents

Some contribution to W(VI)-peroxo-chemistry: Synthesis, spectroscopic characterization, reactivity and DFT studies

Synthesis of white microcrystalline oxodiperoxotungstate(VI) complexes, K[WO(O2)2(L)(H2O)]·H2O, (L ?= ?salicylate, 5-chlorosalicylate, 4-hydroxybenzoate) have been achieved from reaction of Na2WO4·2H2O with 30% H2O2 and the respective hetero-ligands at pH Ca. 7–7.5 in aqueous medium. The newly synthesized compounds were comprehensively characterized by elemental analyses, spectral studies, room temperature magnetic moment measurements and mass spectrometric studies. Infrared spectra suggest that, peroxo groups are bonded to the WO+4 center in a triangular bidentate (C2v) fashion and the hetero-ligands benzene-core hydroxycarboxylic acids viz. salicylic acid, 5-chlorosalicylic acid, 4-hydroxybenzoic acid in anoinic form are coordinated in monodentate manner. Compounds are fairly stable in aqueous solution for sufficient period of time. The results of mass spectrometric analysis lend support to the molecular composition of the complexes ascertained on the basis of elemental analyses and spectroscopic studies. Compound potassium(aquo)(5-chlorosalicylato)oxodiperoxotungstate(VI)monohydrate, K[WO(O2)2(5-chlorosalicylate)(H2O)]·H2O, act as an oxidant of bromide ion in aqueous phase bromination of chosen organic substrates to their corresponding bromo organics. Density Functional Theory (TD-DFT) calculations were performed on the synthesized complexes substantiated the experimentally obtained results. The TD-DFT optimized structures are in excellent agreement with the results of elemental analyses, spectral as well as mass spectrometric data.

Peroxo–tungstate(VI) complexes: syntheses, characterization, reactivity, and DFT studies

Abstract: Three new oxodiperoxo–tungsten(VI) complexes containing benzene core carboxylic acids, viz., benzoic acid, 2-chlorobenzoic acid, and 3-aminobenzoic acid as co-ligands have been synthesized from reaction of Na2WO6H4, 30% H2O2 and the corresponding co-ligands in aqueous medium. The compounds have been comprehensively characterized by elemental analyses, FT-IR, 1H NMR, UV–Vis spectral studies as well as by mass spectrometric and TGA analyses. The infrared spectra suggest occurrence of terminally bonded W=O as well as triangular bidentate peroxo groups (C2v) and monodentate carboxylate group bound to the WO4+ center. The mass spectra of the compounds are in good agreement with proposed molecular formulations. Thermogravimetric analyses indicate the existence of both lattice and coordinated water molecules in the complexes. Density functional theory (DFT) calculations were used to compute the frequencies of relevant vibrational modes, electronic properties and also to investigate structure of the compounds. Compound potassium(aquo)(2-chlorobenzoato)oxodiperoxo–tungstate(VI)dihydrate acts as an oxidant for bromide ion in aqueous phase bromination of chosen organic substrates to their corresponding bromo-organics. Graphical abstract: [Figure not available: see fulltext.]

Highly regioselective C-5 alkynylation of imidazoles by one-pot sequential bromination and Sonogashira cross coupling

A variety of 2-substituted 5-alkynyl-1H-imidazoles were easily prepared by a one-pot sequential procedure involving a highly regioselective electrophilic C-5 bromination of 1,2-dimethyl-1H-imidazole, 2-chloro-1-methyl-1H-imidazole, and 2-aryl-1-methyl-1H-imidazoles, followed by an efficient palladium/copper co-catalyzed Sonogashira-type alkynylation.