162709-22-0Relevant articles and documents
Synthesis method of 8-chloro-1, 7-naphthyridine-3-formaldehyde
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, (2020/04/17)
The invention discloses a synthesis method of 8-chloro-1, 7-naphthyridine-3-formaldehyde, which comprises the following synthesis steps: 1) taking a compound I 2-methoxy-3-aminopyridine as an initialraw material, protecting amino to obtain a compound II; 2) reacting the compound II with an hydroformylation reagent under an alkaline condition to obtain a compound III; 3) deprotecting the compoundIII under an acidic condition to obtain a compound IV or a salt of the compound IV; 4) performing cyclization reaction on the compound IV and an acrylate compound under the action of a Lewis acid to prepare a compound V; 5) carrying out chlorination reaction on the compound V and a chlorination reagent to prepare a compound VI; and 6) dissolving the compound VI 8-chloro-1, 7-naphthyridine-3-formate as a raw material in a solvent, and reducing under the action of a reducing reagent to directly obtain 8-chloro-1, 7-naphthyridine-3-formaldehyde, namely a compound VII. The preparation method disclosed by the invention has the characteristics of suitability for industrial production, relatively low cost and simple operation.
8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
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Page/Page column 141; 142, (2010/09/18)
Provided herein are 8-substituted quinolines and related analogues as sirtuin-modulating compounds of Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.