163719-69-5

Basic information

• Product Name: 3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ART-CHEM-BB B022890;ETHYL 3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE-5-CARBOXYLATE;3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;AKOS B022890;TIMTEC-BB SBB014812;VITAS-BB TBB009126;1,2,4-oxadiazole-5-carboxylic acid, 3-(4-chlorophenyl)-, e;ZERO/009101
• CAS NO: 163719-69-5
• Molecular Formula: C₁₁H₉ClN₂O₃
• Molecular Weight: 252.65
• Mol File: 163719-69-5.mol

Chemical Properties

• Boiling Point: 368.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.327±0.06 g/cm3(Predicted)
• PKA: -4.18±0.25(Predicted)
• CAS DataBase Reference: 3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(163719-69-5)
• EPA Substance Registry System: 3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(163719-69-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 163719-69-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable intermediate in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER is utilized as a key component in the synthesis of agrochemicals. Its versatile nature allows for the creation of compounds with potential applications in crop protection and pest control.
Used in Organic Synthesis:
3-(4-CHLORO-PHENYL)-[1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER is employed as a versatile intermediate in organic synthesis. Its unique structure enables the preparation of a wide range of organic products, contributing to the development of new materials and compounds with various applications across different industries.

Upstream product

• 5033-28-3 4-chlorobenzamidoxime 
• 4755-77-5 Ethyl oxalyl chloride 
• 5033-28-3 4-chloro-N'-hydroxybenzimidamide 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 861146-17-0 3-(4-chlorophenyl)-1,2,4-oxadiazole-5-carbohydrazide 

Relevant articles and documents

Design, Synthesis and Antifungal/Nematicidal Activity of Novel 1,2,4-Oxadiazole Derivatives Containing Amide Fragments

Plant diseases that are caused by fungi and nematodes have become increasingly serious in recent years. However, there are few pesticide chemicals that can be used for the joint control of fungi and nematodes on the market. To solve this problem, a series

Synthesis, spectroscopic characterization and DNA/HSA binding studies of (phenyl/naphthyl)ethenyl-substituted 1,3,4-oxadiazolyl-1,2,4-oxadiazoles

Two new series of conjugated arylethenyl-1,3,4-oxadiazolyl-1,2,4-oxadiazoles were obtained and spectroscopically characterized in terms of UV-Vis absorption, fluorescence and interaction with CT-DNA and Human Serum Albumin (HSA) biomolecules. Phenyl- and 1-naphthyl-bearing examples were analysed, and the spectroscopic properties of its substitution series were compared, showing extensive conjugation in all compounds and absorption differences due to both the aryl-ethenyl subunit and substituted phenyl/phenylene at the 1,2,4-oxadiazole side. Strong binding interactions of the obtained compounds with CT-DNA and moderate HSA-association capability were observed spectroscopically, and further docking studies were performed. This journal is

Ferrocenylethenyl-substituted 1,3,4-oxadiazolyl-1,2,4-oxadiazoles: Synthesis, characterization and DNA-binding assays

This article describes the synthesis, characterization and DNA-binding assays of a series of oxadiazoles derived from (E)-3-ferrocenylacrylic acid. The compounds were obtained in satisfactory yields and characterized by NMR and high resolution mass spectrometry analysis. Additionally, the X-Ray characterization of compound 8a was investigated. A series of ferrocenylethenyl-substituted 1,3,4-oxadiazolyl-1,2,4-oxadiazoles was prepared and studied by UV-visible and electrochemical techniques. The characteristic signals of the redox-active ferrocene/ferrocenium couple were monitored, which allowed verification of the influence of electron-withdrawing oxadiazole heterocycles and their dependence on the 1,2,4-oxadiazole substituent. Also, DNA-binding experiments were performed by UV-vis and emission titrations with ct-DNA.

Some regularities of the synthesis of ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates

Features of amidoximes reactions with ethyl chlorooxalate in a wide range of solvents at the use of a number of bases were investigated. An efficient preparation method for ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates in acetonitrile in the presence of triethylamine was developed.

TRIAZOLE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A triazole derivative of formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has advantageously low toxicity.

Herbicidal oxadiazole carbonamide compounds

The invention pertains to a compound of the general formula STR1 wherein A represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or aralkyl group, or a group of general formula X--Y--(CH2)n -- whe