164012-31-1

Basic information

• Product Name: 6-bromo-4,4-dimethylchroman-2-one
• Synonyms: 6-bromo-4,4-dimethylchroman-2-one
• CAS NO: 164012-31-1
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.11
• Mol File: 164012-31-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-bromo-4,4-dimethylchroman-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-4,4-dimethylchroman-2-one(164012-31-1)
• EPA Substance Registry System: 6-bromo-4,4-dimethylchroman-2-one(164012-31-1)

Safety Data

• Hazardous Substances Data: 164012-31-1(Hazardous Substances Data)

Upstream product

• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 106-41-2 4-bromo-phenol 
• 112090-04-7 3-methyl-but-2-enoic acid 4-bromo-phenyl ester 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 1072453-02-1 7-(4-(3-(2-acetoxy-5-((phosphonomethyl)phosphonoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 925685-20-7 7-(4-(3-(2-(diethylphosphoryloxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 925685-17-2 7-(4-(3-(2-butyroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 925685-14-9 7-(4-(3-(2-(2,2-dimethylacetoxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 925685-11-6 7-(4-(3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 925684-36-2 7-(4-(3-(2-(2,2-dimethylacetoxy)-5-((phosphonomethyl)phosphonoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 925685-18-3 benzyl 3-(2-(diethylphosphoryloxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate 
• 925685-15-0 benzyl 3-(2-butyroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate 
• 925685-12-7 benzyl 3-(2-(2,2-dimethylacetoxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate 
• 925685-19-4 3-(2-(diethylphosphoryloxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid 
• 925685-09-2 benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate 
• 925685-08-1 benzyl 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate 
• 925685-16-1 3-(2-butyroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid 
• 925685-13-8 3-(2-(2,2-dimethylacetoxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid 

Relevant articles and documents

NOVEL 2-AMINO-PYRIDINE AND 2-AMINO-PYRIMIDINE DERIVATIVES AND MEDICINAL USE THEREOF

Provided is a compound superior in an autotaxin inhibitory action and the like, effective as a prophylactic or therapeutic drug for diseases involving ATX. The present invention relates to a compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], which has a superior autotaxin inhibitory action and is useful as a prophylactic or therapeutic drug for diseases involving ATX.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI

Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. The compound can also be used in co-treatment with retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.