164298-41-3

Basic information

• Product Name: 1-TERT-BUTYL 2-METHYL 1,2,3,6-TETRAHYDROPYRIDINE-1,2-DICARBOXYLATE
• Synonyms: 1-TERT-BUTYL 2-METHYL 1,2,3,6-TETRAHYDROPYRIDINE-1,2-DICARBOXYLATE;2-Methyl 1-(2-methyl-2-propanyl) 3,6-dihydro-1,2(2H)-pyridinedica rboxylate
• CAS NO: 164298-41-3
• Molecular Formula: C12H19NO4
• Molecular Weight: 241.28356
• Mol File: 164298-41-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-TERT-BUTYL 2-METHYL 1,2,3,6-TETRAHYDROPYRIDINE-1,2-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TERT-BUTYL 2-METHYL 1,2,3,6-TETRAHYDROPYRIDINE-1,2-DICARBOXYLATE(164298-41-3)
• EPA Substance Registry System: 1-TERT-BUTYL 2-METHYL 1,2,3,6-TETRAHYDROPYRIDINE-1,2-DICARBOXYLATE(164298-41-3)

Safety Data

• Hazardous Substances Data: 164298-41-3(Hazardous Substances Data)

Usage

Appearance

White solid Describes the physical form and color of the compound, which is a white solid substance.

Solubility

Soluble in organic solvents Indicates the compound can dissolve in certain organic solvents, which is important for its use in chemical reactions and processes.

Toxicity

Relatively low toxicity Suggests that the compound is not highly toxic or harmful to living organisms, which is a desirable property for many applications.

Molecular structure

Tert-butyl and methyl groups on the 1,2,3,6-tetrahydropyridine ring Describes the specific arrangement of the tert-butyl and methyl groups attached to the central pyridine ring, which influences the compound's chemical properties and reactivity.

Carboxylate groups

Two carboxylate groups Highlights the presence of two negatively charged carboxylate groups in the compound, which can participate in various chemical reactions and contribute to its solubility in organic solvents.

Uses

Intermediate in organic synthesis Indicates that the compound is commonly used as an intermediate in the synthesis of more complex organic molecules, which is a key role in the production of pharmaceuticals and agrochemicals.

Applications

Production of various pharmaceuticals and agrochemicals Suggests that the compound has a wide range of potential applications in the fields of medicine and agriculture, making it a versatile and valuable chemical.

Upstream product

• 164298-38-8 N-allyl-N-(tert-butoxycarbonyl)-4,5-didehydro-DL-norvaline methyl ester 
• 136918-14-4 phthalimide 
• 181269-87-4 1-tert-butyl 2-methyl cis-4-hydroxypiperidine-1,2-dicarboxylate 
• 106928-50-1 methyl 2-[(tert-butoxycarbonyl)amino]pent-4-enoate 
• 188194-85-6 (R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester 
• 81136-73-4 (R)-2-allylglycine methyl ester 
• 188194-82-3 (R)-2-Allylamino-pent-4-enoic acid methyl ester 
• 198646-60-5 (S)-1-(tertbutyloxycarbonyl)-4-oxo-piperidine-2-carboxylic acid 
• 1799811-83-8 1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate 
• 1448668-01-6 1-tert-butyl 2-methyl (2S)-4-hydroxypiperidine-1,2-dicarboxylate 
• 67-56-1 methanol 
• 417726-36-4 (S)-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine-2-carboxylic acid 

Downstream Products

• 417726-36-4 (S)-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine-2-carboxylic acid 

Relevant articles and documents

An efficient method for removal of ruthenium byproducts from olefin metathesis reactions

(Matrix presented) Sequential treatment of the ring-closing metathesis reaction products with silica gel, activated carbon (50 equiv wt relative to the crude products), and column chromatography on silica gel efficiently removed dark brown ruthenium bypro

Application of ring-closing metathesis to the synthesis of rigidified amino acids and peptides

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AZABICYCLO [4.1.0] HEPT - 4 - YL DERIVATIVES AS HUMAN OREXIN RECEPTOR ANTAGONISTS

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NOVEL COMPOUNDS

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Synthesis of free and Nα-Fmoc-/Nγ-Boc- protected (2S,4S)- and (2S,4R)-4-aminopipecolic acids

The preparation of (2S,4S)- and (2S,4R)-4-aminopipecolic acid, a conformationally constrained basic amino acid bearing orthogonal N α/Nγ-protection suitable for solid-phase peptide synthesis, is reported. These amino acids were synthesised from enantiopure ethyl (2S)-4-oxo-1-(1-phenylethyl)-piperidine-2-carboxylate (1) with introduction of the side-chain amino group by reductive amination, followed by protection/deprotection of the functional groups. A mixture of Fmoc-Sly(Boc)-OH 6 and 7 was used to establish their compatibility in solid-phase peptide synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Ruthenium-catalyzed ring closing olefin metathesis of non-natural α-amino acids

The use of various enantiopure amino acid-derived diolefins as substrates for the ring closing olefin metathesis reaction (RCM) has been investigated. This reaction has been shown to be an efficient transformation for providing highly functionalized 6- and 7-membered ring amino acids.