1644060-37-6 Usage
Uses
Used in Pharmaceutical Industry:
Fumarate hydratase-IN-1 is used as a therapeutic agent for the treatment of cancer. Its application is based on its ability to inhibit fumarate hydratase, an enzyme crucial for the energy production and proliferation of cancer cells. By disrupting the TCA cycle, Fumarate hydratase-IN-1 can lead to the accumulation of metabolic intermediates and induce cell death, making it a potential candidate for cancer therapy.
Used in Drug Development:
Fumarate hydratase-IN-1 is used as a target for drug development in the pharmaceutical industry. Research has implicated fumarate hydratase in certain types of cancer, highlighting its potential as a target for the development of new cancer treatments. Fumarate hydratase-IN-1's ability to inhibit fumarate hydratase and disrupt the TCA cycle makes it a valuable asset in the search for novel anticancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1644060-37-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,4,4,0,6 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1644060-37:
(9*1)+(8*6)+(7*4)+(6*4)+(5*0)+(4*6)+(3*0)+(2*3)+(1*7)=146
146 % 10 = 6
So 1644060-37-6 is a valid CAS Registry Number.
1644060-37-6Relevant articles and documents
Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity
Takeuchi, Toshifumi,Schumacker, Paul T.,Kozmin, Sergey A.
, p. 564 - 567 (2015/01/30)
Development of cell-permeable small molecules that target enzymes involved in energy metabolism remains important yet challenging. We describe here the discovery of a new class of compounds with a nutrient-dependent cytotoxicity profile that arises from p
