164513-41-1

Basic information

• Product Name: 2-broMo-5-(diMethylaMino)benzoic acid Methyl ester
• Synonyms: 2-broMo-5-(diMethylaMino)benzoic acid Methyl ester;Methyl 2-bromo-5-(dimethylamino)benzoate
• CAS NO: 164513-41-1
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258
• Mol File: 164513-41-1.mol

Chemical Properties

• Boiling Point: 337.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.422±0.06 g/cm3(Predicted)
• PKA: 2.92±0.22(Predicted)
• CAS DataBase Reference: 2-broMo-5-(diMethylaMino)benzoic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-5-(diMethylaMino)benzoic acid Methyl ester(164513-41-1)
• EPA Substance Registry System: 2-broMo-5-(diMethylaMino)benzoic acid Methyl ester(164513-41-1)

Safety Data

• Hazardous Substances Data: 164513-41-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-5-(dimethylamino)benzoic acid methyl ester is used as an intermediate in the synthesis of various organic compounds for the development of pharmaceuticals. Its unique chemical structure allows it to be a versatile building block in the creation of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-bromo-5-(dimethylamino)benzoic acid methyl ester is utilized for its potential applications in the design and synthesis of novel compounds with therapeutic properties. Its reactivity and functional groups make it a valuable component in the development of new pharmaceuticals.
Safety Precautions:
It is important to handle and store 2-bromo-5-(dimethylamino)benzoic acid methyl ester with proper safety measures, as it may be harmful if ingested, inhaled, or absorbed through the skin. Appropriate personal protective equipment (PPE) and handling procedures should be followed to minimize the risk of exposure and ensure the safety of those working with this chemical compound.

Upstream product

• 16518-64-2 3-(dimethylamino)benzoic acid methyl ester 
• 99-64-9 3-(dimethylamino)benzoic acid 
• 74-88-4 methyl iodide 
• 6942-39-8 methyl 2-bromo-5-fluorobenzoate 
• 506-59-2 N,N-dimethylammonium chloride 
• 67-68-5 dimethyl sulfoxide 
• 50-00-0 formaldehyd 
• 6942-37-6 5-amino-2-bromo-benzoic acid methyl ester 

Downstream Products

• 163913-92-6 5-(N,N-dimethylamino)-2-bromobenzyl alcohol 
• 1012869-88-3 2-Cyano-5-dimethylamino-benzoic acid methyl ester 
• 1189353-21-6 4-bromo-3-(methoxymethyl)-N,N-dimethylaniline 
• 1189166-13-9 C₂₀H₂₇N₃O₄S 
• 1189166-12-8 C₂₁H₂₇N₃O₅S 
• 1189165-85-2 2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol 
• 1189166-11-7 methyl 2-(aminocarbonothioyl)-5-(dimethylamino)benzoate 
• 163913-96-0 2-(2-Bromo-5-dimethylamino-benzyl)-3-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-but-3-enoic acid methoxy-methyl-amide 
• 1012869-51-0 trifluoromethanesulfonate (4-bromo-3-methoxycarbonylphenyl)trimethylammonium 
• 163914-14-5 1-bromo-2-(bromomethyl)-4-(dimethylamino)benzene 

Relevant articles and documents

Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides

The special reactivity of N,N-dialkylaniline N-oxides allows practical and convenient access to electron-rich aryl halides. A complementary pair of reaction protocols allow for the selective para-bromination or ortho-chlorination of N,N-dialkylanilines in up to 69% isolated yield. The generation of a diverse array of halogenated anilines is made possible by a temporary oxidation level increase of N,N-dialkylanilines to the corresponding N,N-dialkylaniline N-oxides and the excision of the resultant weak N-O bond via treatment with thionyl bromide or thionyl chloride at low temperature.

2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF

The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumo

2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF

The present invention discloses fused heterobicyclic 2-aryl- and 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcino

Compounds and methods for F labelled agents

This invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula 11, wherein the subs

Synthesis and photochromic properties of 2H,9H-indeno[1,2-f]- and 3H,7H-indeno[2,1-i]-naphtho[2,1-b]pyrans

Expedient syntheses of the 3-hydroxy- and 6-hydroxy- derivatives of 11H-benzo[a]-fluoren-11-one, obtained via Suzuki-Miyaura couplings are described. Reactions of these phenols with 1,1-diarylprop-2-yn-1-ols give indeno[2,1-i]- and indeno[1,2-f]-naphtho[2

Preparation of E-(2-substituted-1-methylethylidene)indanones derived from monic acid

Alkylation of the lithium dienolate of the monic acid hydroxamate (3) with o-bromo(bromomethyl) benzene or heteroaromatic derivatives gave α-alkylated products (5). This alkylation procedure was surprisingly catalysed by 4- dimethylaminopyridine. Metal-halogen exchange with t-butyl lithium occurred with concomitant intramolecular cyclisation to give a mixture of the deconjugated ketones (6). Reconjugation with potassium t-butoxide stereoselectively produced the E-isomer (7). Deprotection gave the monic acid derived ketone (1).