165065-08-7 Usage
Uses
Used in Pharmaceutical Industry:
2'-O-(tert-Butyldimethylsilyl)-6a-hydroxy-7-epi-paclitaxel is used as a chemotherapeutic agent for the treatment of various types of cancer. Its paclitaxel-like structure allows it to target and stabilize microtubules, inhibiting cell division and leading to cancer cell death.
Used in Drug Delivery Systems:
2'-O-(tert-Butyldimethylsilyl)-6a-hydroxy-7-epi-paclitaxel is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of paclitaxel. The tert-butyldimethylsilyl group enhances the lipophilicity of the molecule, facilitating its transport across biological barriers and increasing its therapeutic efficacy.
Used in Research and Development:
2'-O-(tert-Butyldimethylsilyl)-6a-hydroxy-7-epi-paclitaxel is used as a research compound for studying the structure-activity relationship of paclitaxel and its derivatives. Its unique chemical modifications provide insights into the design and development of new anticancer agents with improved properties and reduced side effects.
Used in Cosmetic Industry:
Although not explicitly mentioned in the provided materials, the paclitaxel-like structure of 2'-O-(tert-Butyldimethylsilyl)-6a-hydroxy-7-epi-paclitaxel may have potential applications in the cosmetic industry for its anti-aging and skin rejuvenation properties. However, further research and safety assessments would be required to confirm its suitability for cosmetic use.
Check Digit Verification of cas no
The CAS Registry Mumber 165065-08-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,0,6 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 165065-08:
(8*1)+(7*6)+(6*5)+(5*0)+(4*6)+(3*5)+(2*0)+(1*8)=127
127 % 10 = 7
So 165065-08-7 is a valid CAS Registry Number.
165065-08-7Relevant articles and documents
Paclitaxel analogs modified in ring C: Synthesis and biological evaluation
Liang, Xian,Kingston, David G.I.,Long, Byron H.,Fairchild, Craig A.,Johnston, Kathy A.
, p. 3441 - 3456 (2007/10/03)
Lead tetracetate oxidation of 6α-hydroxy-7-epi-paclitaxel lends to C-nor-paclitaxel and C-seco-paclitaxel derivatives. Tetrpropylammonium perruthnate (TPAP) oxidation of a 6α-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6α-O-trifluoromethanesulfonyl-7-epi-paclitaxel derivative with DMAP yields a 20-O-acetyl-4-deacetyl-5,6-dehydro-6-formyl-C-nor-paclitaxel derivative. C-nor-paclitaxel analogs are less active than paclitaxel.
Synthesis of novel taxol analogs and evaluation of their biological activities
Wender, Paul A.,Lee, Daesung,Lal, Tapan K.,Horwitz, Susan B.,Rao, Srinivasa
, p. 1941 - 1944 (2007/10/03)
Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibi
An Interesting C-Ring Contraction in Paclitaxel (Taxol)
Chen, Shu-Hui,Huang, Stella,Roth, Gregory P.
, p. 8933 - 8936 (2007/10/02)
An interesting pinacol rearrangement involving 7-epi-6α-tosylate/triflate-paclitaxel derivatives (6) and (10), with the formation of five-membered C-ring containing analogs (7) and (11), is described.
Synthesis and Biological Evaluation of Paclitaxel Analogs Modified in Ring C
Liang, Xian,Kingston, David G. I.,Lin, Chii M.,Hamel, Ernest
, p. 2901 - 2904 (2007/10/02)
Both 7-deoxy-7α-azidopaclitaxel (6) and 7-deoxy-Δ6,7-paclitaxel (4) can be prepared from paclitaxel-7-O-triflate (2b).Oxidation of 7-deoxy-Δ6,7-paclitaxel with dioxirane yields the epoxide 7, while oxidation with osmium tetroxide yie
