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171021-22-0

6-O-acetyl-2'-O-(t-butyldimethylsilyl)-C-nor-paclitaxel is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 171021-22-0 Structure

  • Basic information

    1. Product Name: 6-O-acetyl-2'-O-(t-butyldimethylsilyl)-C-nor-paclitaxel
    2. Synonyms: 6-O-acetyl-2'-O-(t-butyldimethylsilyl)-C-nor-paclitaxel
    3. CAS NO:171021-22-0
    4. Molecular Formula:
    5. Molecular Weight: 996.193
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 171021-22-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-O-acetyl-2'-O-(t-butyldimethylsilyl)-C-nor-paclitaxel(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-O-acetyl-2'-O-(t-butyldimethylsilyl)-C-nor-paclitaxel(171021-22-0)
    11. EPA Substance Registry System: 6-O-acetyl-2'-O-(t-butyldimethylsilyl)-C-nor-paclitaxel(171021-22-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 171021-22-0(Hazardous Substances Data)

171021-22-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 171021-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,0,2 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 171021-22:
(8*1)+(7*7)+(6*1)+(5*0)+(4*2)+(3*1)+(2*2)+(1*2)=80
80 % 10 = 0
So 171021-22-0 is a valid CAS Registry Number.

171021-22-0Downstream Products

171021-22-0Relevant articles and documents

Paclitaxel analogs modified in ring C: Synthesis and biological evaluation

Liang, Xian,Kingston, David G.I.,Long, Byron H.,Fairchild, Craig A.,Johnston, Kathy A.

, p. 3441 - 3456 (2007/10/03)

Lead tetracetate oxidation of 6α-hydroxy-7-epi-paclitaxel lends to C-nor-paclitaxel and C-seco-paclitaxel derivatives. Tetrpropylammonium perruthnate (TPAP) oxidation of a 6α-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6α-O-trifluoromethanesulfonyl-7-epi-paclitaxel derivative with DMAP yields a 20-O-acetyl-4-deacetyl-5,6-dehydro-6-formyl-C-nor-paclitaxel derivative. C-nor-paclitaxel analogs are less active than paclitaxel.

Synthesis, Structure Elucidation and Biological Evaluation of C-Norpaclitaxel

Liang, Xian,Kingston, David G. I.,Long, Byron H.,Fairchild, Craig A.,Johnston, Kathy A.

, p. 7795 - 7798 (2007/10/02)

Oxidation of 2'-TBDMS-6α-hydroxy-7-epipaclitaxel (1) with lead tetraacetate furnished 2'-TBDMS-C-norpaclitaxel (2) and the C-seco compound 3.Deprotection of 2 with pyridinium hydrofluoride yielded C-norpaclitaxel (4).C-norpaclitaxel (4) is less effective at promoting the assembly of microtubules and less cytotoxic towards HCT116 cells than paclitaxel.

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