165071-36-3

Basic information

• Product Name: phenyl 3-iodobenzoate
• Synonyms: phenyl 3-iodobenzoate
• CAS NO: 165071-36-3
• Molecular Formula: C₁₃H₉IO₂
• Molecular Weight: 324.11383
• Mol File: 165071-36-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: phenyl 3-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 3-iodobenzoate(165071-36-3)
• EPA Substance Registry System: phenyl 3-iodobenzoate(165071-36-3)

Safety Data

• Hazardous Substances Data: 165071-36-3(Hazardous Substances Data)

Upstream product

• 1711-10-0 3-iodobenzoyl chloride 
• 108-95-2 phenol 
• 618-51-9 3-Iodobenzoic acid 

Downstream Products

• 341989-93-3 (4-hydroxyphenyl)(3-iodophenyl)methanone 

Relevant articles and documents

Nickel-Catalyzed Cross-Coupling of Aryl Redoxactive Esters with Aryl Zinc Reagents

A nickel-catalyzed aryl-aroyloxyl C(sp2)-O radical cross-coupling reaction conducted using a redox active ester with aryl zinc reagent was developed. This method demonstrates a new disconnection approach for formation of aryl aryl esters. In the one-pot sequential process, the readily available aryl carboxylic acids can be converted into functionalized aryl aryl esters and heteroaryl esters. This protocol is amenable to the gram-scale synthesis. The present method has a wide substrate scope and high functional group tolerance.

Transesterification of (hetero)aryl esters with phenols by an Earth-abundant metal catalyst

Readily available and inexpensive Earth-abundant alkali metal species are used as efficient catalysts for the transesterification of aryl or heteroaryl esters with phenols which is a challenging and underdeveloped transformation. The simple conditions and the use of heterogeneous alkali metal catalyst make this protocol very environmentally friendly and practical. This reaction fills in the missing part in transesterification reaction of phenols and provides an efficient approach to aryl esters, which are widely used in the synthetic and pharmaceutical industry.

Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands

Para-substituted aromatic ethers with benzophenone or related structural elements and a 3-(1H-imidazol-4-yl)propyloxy moiety were prepared by Mitsunobu-type ether synthesis or SNAr reaction. Most of the title compounds possess high antagonist potency in histamine H3-receptor assays in vitro as well as in vivo in mouse CNS following oral administration. After defining 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl phenyl methanone as a new lead, structure-activity relationships were investigated for this new class of compounds. Substitution of the meta′-position of the benzophenone moiety with halogen atoms (e.g., iodine, fluorine) led to compounds with high antagonist potency in vitro as well as in vivo (Ki = 9.3 and 4.3 nM, ED50 = 0.7 and 0.47 mg/kg p.o., 18 and 12, respectively). A receptor profile of several functional in vitro assays for several biogenic amine receptors for the meta′-iodinated derivative demonstrated high selectivity toward the histamine H3 receptor.