16621-37-7

Basic information

• Product Name: 1-(ethylthio)propan-2-ol
• Synonyms: 1-(ethylthio)propan-2-ol;1-(Ethylthio)-2-propanol
• CAS NO: 16621-37-7
• Molecular Formula: C₅H₁₂OS
• Molecular Weight: 120.21318
• EINECS: 240-670-3
• Mol File: 16621-37-7.mol

Chemical Properties

• Boiling Point: 191.3 °C at 760 mmHg
• Flash Point: 94 °C
• Appearance: /
• Density: 0.977 g/cm³
• Vapor Pressure: 0.139mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: 1-(ethylthio)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(ethylthio)propan-2-ol(16621-37-7)
• EPA Substance Registry System: 1-(ethylthio)propan-2-ol(16621-37-7)

Safety Data

• Hazardous Substances Data: 16621-37-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1-(Ethylthio)propan-2-ol is utilized as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of a wide array of organic compounds.
Used as a Solvent:
In the chemical industry, 1-(ethylthio)propan-2-ol serves as a solvent in numerous processes, facilitating the dissolution of other substances and aiding in the smooth progression of chemical reactions.
Used in Pharmaceutical Production:
1-(Ethylthio)propan-2-ol is employed as a precursor in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds.
Used in Laboratory Research:
1-(ethylthio)propan-2-ol is also valuable in laboratory settings, where it is used for research purposes, including the development of new chemical processes and the study of organic reactions.

InChI:InChI=1/C5H12OS/c1-3-7-4-5(2)6/h5-6H,3-4H2,1-2H3

Upstream product

• 18863-41-7 triethylamine; diethyl tetrathiophosphate 
• 75-56-9 methyloxirane 
• 75-08-1 ethanethiol 
• 850998-07-1 2-acetyl-3,3-bis-ethylsulfanyl-N-o-tolyl-acrylamide 
• 75-03-6 ethyl iodide 
• 1068-47-9 propanol-⁽²⁾-thiol-⁽¹⁾ 
• 86852-11-1 diethoxyltriphenylphosphorane 
• 811-51-8 sodium thioethylate 
• 127-00-4 1-Chloro-2-propanol 
• 20996-62-7 1-(ethylthio)acetone 

Relevant articles and documents

NaOH-promoted thiolysis of oxiranes using 2-[bis(alkylthio)methylene]-3- oxo-N-o-tolylbutanamides as odorless thiol equivalents

A convenient and efficient protocol for the thiolysis of oxiranes using 2-[bis(alkylthio)methylene]-3-oxo-N-o-tolylbutanamides as thiol equivalents has been developed. Promoted by sodium hydroxide (NaOH) in ethanol at room temperature, the cleavage commences and the generated thiolate anions undergo nucleophilic addition in situ. β-Hydroxy Sulfides were obtained in high yields along with good β-regioselectivity, and trans β-hydroxy Sulfides were also isolated. The thiolysis of one α,β-epoxyketone product with the thiol equivalents was accomplished to afford the corresponding α-carbonyl sulfides in excellent yields. In all the cases, 3-oxo-N-o-tolylbutanamide, the precursor of the thiol equivalents, could be recovered in the novel thiolysis process as a byproduct in good yield. Georg Thieme Verlag Stuttgart.

Humicola lanuginosa lipase-catalyzed enantioselective resolution of β-hydroxy sulfides: Versatile synthons for enantiopure β-hydroxy sulfoxides

Humicola lanuginosa lipase-catalyzed acylation of β-hydroxy sulfides provides both the (R)- and (S)-enantiomers in high enantiomeric purity. In two cases the resolved hydroxy sulfides were oxidized to give β-hydroxy sulfoxides in >99% e.e. The effect of substituents on enantioselectivity is discussed.

The Use of Proton-exchanged X-Type Zeolite in Catalysing Ring-opening Reactions of 2-Substituted Epoxides with Nucleophiles and its Effect on Regioselectivity

The use of proton-exchanged X-type zeolite in catalysing ring-opening reactions of 2-alkyl substituted epoxides with nucleophiles gives a high regioselectivity and functional-selective catalysis giving allylic products from allylic nucleophiles.Mechanistic aspects are discussed.

NEW ROUTE TO THE PREPARATION OF 1,3,2 OXATHIAPHOSPHOLANES 2-SULFIDE DERIVATIVES

5-Substituted 2-alkyl (or aryl, heteroaryl,...)thio 1,3,2 oxathiaphospholanes 2-sulfide 5 are readily accessible by reaction of the triethylammonium salt 1 of a diester of the phosphorotetrathioic acid with appropriate epoxide in the presence of BF3*Et2O as catalyst.

SYNTHESIS OF 1,3,2-OXATHIAPHOSPHOLANE-2-SULFIDE DERIVATIVES

5-Substituted 2-alkyl (or aryl, heteroaryl, ...)thio-1,3,2-oxathiaphospholane-2-sulfides 5 are readily accessible by reaction of the triethylammonium salt 1 of a diester of the phosphorotetrathioic acid with appropriate epoxides in the presence of BF3/Et2O as catalyst.Key words: BF3/Et2O; cyclisation reaction; NMR; oxathiaphospholane derivatives; oxiranes; phosphorotetrathioic acid; triethylammonium salts.

THE CHEMISTRY OF α,ω-MERCAPTOALCOHOLS IN THE PRESENCE OF DIETHOXYTRIPHENYLPHOSPHORANE. TEMEPERATURE DEPENDENCE OF CYCLODEHYDRATIONS AND S-ETHYLATIONS

Diethoxytriphenylphosphorane (DTPP) is easily prepared by oxidative addition of triphenylphosphine with diethyl peroxide.DTPP converts a variety of mercaptoalcohols to cyclic sulfides as well as hydroxythioethers.The temperature dependence (+25 --> -25 deg C) of the product distribution has synthetic petential.