166251-34-9

Basic information

• Product Name: 3-(4-FLUORO-2-METHYL-PHENYL)-PROPIONIC ACID
• Synonyms: 3-(4-FLUORO-2-METHYL-PHENYL)-PROPIONIC ACID;3-(4-Fluoro-2-Methylphenyl)propanoic acid
• CAS NO: 166251-34-9
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.19
• Mol File: 166251-34-9.mol

Chemical Properties

• Boiling Point: 299.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.184±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.68±0.10(Predicted)
• CAS DataBase Reference: 3-(4-FLUORO-2-METHYL-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-2-METHYL-PHENYL)-PROPIONIC ACID(166251-34-9)
• EPA Substance Registry System: 3-(4-FLUORO-2-METHYL-PHENYL)-PROPIONIC ACID(166251-34-9)

Safety Data

• Hazardous Substances Data: 166251-34-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Fluoro-2-methyl-phenyl)-propionic acid is used as an active pharmaceutical ingredient for the development of medications aimed at relieving pain and reducing inflammation. Its application is particularly relevant in conditions such as arthritis, where it helps to alleviate the discomfort and swelling associated with the disease.
Additionally, it is utilized in formulations for menstrual cramps, providing relief from the pain and inflammation that can accompany this physiological process.
Used in Pain Management:
3-(4-Fluoro-2-methyl-phenyl)-propionic acid serves as a key component in pain management therapies, where its analgesic properties are leveraged to provide relief from various types of pain, including but not limited to musculoskeletal and postoperative pain.
Used in Antipyretic Treatments:
In the context of fever management, 3-(4-Fluoro-2-methyl-phenyl)-propionic acid is used as an antipyretic agent to reduce elevated body temperatures, thereby providing comfort and aiding in the recovery process from illnesses associated with fever.

Upstream product

• 63082-45-1 4-fluoro-2-methylbenzaldehyde 
• 500102-62-5 (E)-ethyl 3-(4-fluoro-2-methylphenyl)acrylate 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 174603-41-9 ethyl 3-(4-fluoro-2-methylphenyl)propionate 

Downstream Products

• 174603-42-0 6-fluoro-4-methyl-1-indanone 

Relevant articles and documents

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.

Indanylidenes. 2. Design and synthesis of (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity

Extension of the structure-activity relationship studies that led to the discovery of the nonsedating potent muscle relaxant, antiinflammatory, and analgesic agent (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 1, has given rise to (E)-2-(4-chloro-6-fluoro

Amide derivatives and their therapeutic use

A compound of formula (I), wherein R1 and R2 are independently selected from chloro, fluoro, bromo, C1-6 alkyl, C1-6 alkoxy or C1-6 haloalkyl provided that both R1 and R2 are not