16665-43-3

Basic information

• Product Name: 4-Ethoxypicolinaldehyde
• Synonyms: 4-Ethoxypicolinaldehyde;4-ethoxypyridine-2-carbaldehyde
• CAS NO: 16665-43-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Mol File: 16665-43-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Ethoxypicolinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Ethoxypicolinaldehyde(16665-43-3)
• EPA Substance Registry System: 4-Ethoxypicolinaldehyde(16665-43-3)

Safety Data

• Hazardous Substances Data: 16665-43-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Manufacturing:
4-Ethoxypicolinaldehyde is used as an important raw material in the pharmaceutical industry for its role in organic synthesis. Its unique chemical structure and properties make it a valuable component in the development and production of various pharmaceutical products.
Used in Organic Synthesis:
In the field of organic chemistry, 4-Ethoxypicolinaldehyde is employed as a key intermediate in the synthesis of complex organic molecules. Its versatility in forming different chemical bonds and its reactivity with other compounds contribute to its significance in creating a wide range of organic compounds for various applications.

Upstream product

• 931-19-1 2-methylpyridine N-oxide 
• 19677-69-1 (4-ethoxypyridin-2-yl)methanol 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 98197-88-7 4-nitro-2-(hydroxymethyl)pyridine 

Relevant articles and documents

ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS

Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.

Tuning of the properties of transition-metal bispidine complexes by variation of the basicity of the aromatic donor groups

Bispidines (3,7-diazabicyclo[3.3.1]nonanes) as very rigid and highly preorganized ligands find broad application in the field of coordination chemistry, and the redox potentials of their transition-metal complexes are of importance in oxidation reactions by high-valent iron complexes, aziridination catalyzed by copper complexes, and imaging by 64Cu positron emission tomography tracers. Here, we show that the redox potentials and stability constants of the copper(II) complexes of 15 tetradentate bispidines can be varied by substitution of the pyridine rings (variation of the redox potential over ca. 450 mV and of the complex stability over approximately 10 log units). It is also shown that these variations are predictable by the pKa values of the pyridine groups as well as by the Hammett parameters of the substituents, and the density functional theory based energy decomposition analysis also allows one to accurately predict the redox potentials and concomitant complex stability. It is shown that the main contribution emerges from the electrostatic interaction energy, and the partial charges of the pyridine donor groups therefore also correlate with the redox potentials.