166665-94-7

Basic information

• Product Name: pazufloxacin
• Synonyms: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (R)- (9CI)
• CAS NO: 166665-94-7
• Molecular Formula: C16H15 F N2 O4
• Molecular Weight: 318.3
• Mol File: 166665-94-7.mol

Chemical Properties

• Melting Point: 269-271℃
• Boiling Point: 531.5°C at 760 mmHg
• Flash Point: 275.2°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 4E-12mmHg at 25°C
• Refractive Index: 1.692
• PKA: 5.05±0.40(Predicted)
• CAS DataBase Reference: pazufloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: pazufloxacin(166665-94-7)
• EPA Substance Registry System: pazufloxacin(166665-94-7)

Safety Data

• Hazardous Substances Data: 166665-94-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)

Upstream product

• 127046-25-7 10-(1-benzyloxycarbonylaminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 
• 127045-64-1 ethyl 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoate 
• 127045-52-7 ethyl 4-(1-diphenylmethoxycarbonylvinyl)-2,3,5-trifluorobenzoate 
• 127045-84-5 (Z)-2-[4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,3,5-trifluoro-benzoyl]-3-(2-hydroxy-1-methyl-ethylamino)-acrylic acid ethyl ester 
• 127045-58-3 ethyl 4-(1-diphenylmethoxycarbonylcyclopropyl)-2,3,5-trifluorobenzoate 
• 127045-79-8 ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate 
• 1026311-06-7 {1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester 
• 123161-40-0 ethyl 4-diphenylmethoxycarbonylmethyl-2,3,5-trifluorobenzoate 
• 1027658-23-6 4-(1-Ethoxycarbonyloxycarbonyl-cyclopropyl)-2,3,5-trifluoro-benzoic acid ethyl ester 
• 127045-73-2 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid 
• 1027026-06-7 4-(1-Azidocarbonyl-cyclopropyl)-2,3,5-trifluoro-benzoic acid ethyl ester 
• 127045-61-8 ethyl 4-(1-carboxycyclopropyl)-2,3,5-trifluorobenzoate 
• 123161-38-6 ethyl 4-carboxymethyl-2,3,5-trifluorobenzoate 
• 122894-73-9 ethyl 2,3,4,5-tetrafluorobenzenecarboxylate 

Downstream Products

• 127046-18-8 ethyl (S)-9-fluoro-3,7-dihydro-3-methyl-10-(1-aminocyclopropyl)-7-oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 

Relevant articles and documents

Pyridonecarboxylic acids as antibacterial agents. IX. Synthesis and structure-activity relationship of 3-substituted 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] -1,4-benzoxazine-6-carboxylic acids and their 1-thio and 1-aza anal

A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo efficacy of 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] -1,4-benzoxazi

Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids

4-Oxo-1,8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-aminocyclopropyl group at the 7-position have been synthesized and evaluated for in vitro antibacterial activities. The three quinolones (3d, h, i) exhibited potent antibacterial activities against both gram-positive and gram-negative bacteria, which are comparable to those of ciprofloxacin (CPFX) and ofloxacin (OFLX). Among the three compounds, the best pharmacological and pharmacokinetic profile was obtained with 3i, an OFLX analogue, which was considerably less toxic than three reference quinolones (1, CPFX, and OFLX).