127045-79-8

Basic information

• Product Name: ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate
• CAS NO: 127045-79-8
• Molecular Weight: 435.4
• Mol File: 127045-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate(127045-79-8)
• EPA Substance Registry System: ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate(127045-79-8)

Safety Data

• Hazardous Substances Data: 127045-79-8(Hazardous Substances Data)

Upstream product

• 37517-78-5 magnesium bis(3-ethoxy-3-oxopropanoate) 
• 1026311-06-7 {1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester 
• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 122894-73-9 ethyl 2,3,4,5-tetrafluorobenzenecarboxylate 
• 123161-38-6 ethyl 4-carboxymethyl-2,3,5-trifluorobenzoate 
• 127045-61-8 ethyl 4-(1-carboxycyclopropyl)-2,3,5-trifluorobenzoate 
• 1027026-06-7 4-(1-Azidocarbonyl-cyclopropyl)-2,3,5-trifluoro-benzoic acid ethyl ester 
• 127045-73-2 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid 
• 1027658-23-6 4-(1-Ethoxycarbonyloxycarbonyl-cyclopropyl)-2,3,5-trifluoro-benzoic acid ethyl ester 
• 127045-64-1 ethyl 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoate 
• 127045-52-7 ethyl 4-(1-diphenylmethoxycarbonylvinyl)-2,3,5-trifluorobenzoate 
• 123161-40-0 ethyl 4-diphenylmethoxycarbonylmethyl-2,3,5-trifluorobenzoate 
• 127045-58-3 ethyl 4-(1-diphenylmethoxycarbonylcyclopropyl)-2,3,5-trifluorobenzoate 

Downstream Products

• 127045-41-4 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 
• 127046-25-7 10-(1-benzyloxycarbonylaminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 
• 133225-03-3 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 133225-08-8 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 127070-77-3 9-(1-Benzyloxycarbonylamino-cyclopropyl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid ethyl ester 

Relevant articles and documents

Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids

4-Oxo-1,8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-aminocyclopropyl group at the 7-position have been synthesized and evaluated for in vitro antibacterial activities. The three quinolones (3d, h, i) exhibited potent antibacterial activities against both gram-positive and gram-negative bacteria, which are comparable to those of ciprofloxacin (CPFX) and ofloxacin (OFLX). Among the three compounds, the best pharmacological and pharmacokinetic profile was obtained with 3i, an OFLX analogue, which was considerably less toxic than three reference quinolones (1, CPFX, and OFLX).