127045-58-3

Upstream product

• 70775-39-2 dimethylsulfoxonium methylide 
• 127045-52-7 ethyl 4-(1-diphenylmethoxycarbonylvinyl)-2,3,5-trifluorobenzoate 
• 122894-73-9 ethyl 2,3,4,5-tetrafluorobenzenecarboxylate 
• 123161-40-0 ethyl 4-diphenylmethoxycarbonylmethyl-2,3,5-trifluorobenzoate 
• 123161-38-6 ethyl 4-carboxymethyl-2,3,5-trifluorobenzoate 
• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 

Downstream Products

• 127045-84-5 (Z)-2-[4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,3,5-trifluoro-benzoyl]-3-(2-hydroxy-1-methyl-ethylamino)-acrylic acid ethyl ester 
• 127070-77-3 9-(1-Benzyloxycarbonylamino-cyclopropyl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid ethyl ester 
• 133225-08-8 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 133225-03-3 7-(1-Benzyloxycarbonylamino-cyclopropyl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 127046-25-7 10-(1-benzyloxycarbonylaminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 
• 127045-79-8 ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate 
• 1026311-06-7 {1-[2,3,6-Trifluoro-4-(imidazole-1-carbonyl)-phenyl]-cyclopropyl}-carbamic acid benzyl ester 
• 127045-64-1 ethyl 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoate 
• 1027658-23-6 4-(1-Ethoxycarbonyloxycarbonyl-cyclopropyl)-2,3,5-trifluoro-benzoic acid ethyl ester 
• 127045-73-2 4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoic acid 
• 127045-41-4 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 
• 1027026-06-7 4-(1-Azidocarbonyl-cyclopropyl)-2,3,5-trifluoro-benzoic acid ethyl ester 
• 127045-61-8 ethyl 4-(1-carboxycyclopropyl)-2,3,5-trifluorobenzoate 

Relevant academic research and scientific papers

Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids

4-Oxo-1,8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-aminocyclopropyl group at the 7-position have been synthesized and evaluated for in vitro antibacterial activities. The three quinolones (3d, h, i) exhibited potent antibacterial activities against both gram-positive and gram-negative bacteria, which are comparable to those of ciprofloxacin (CPFX) and ofloxacin (OFLX). Among the three compounds, the best pharmacological and pharmacokinetic profile was obtained with 3i, an OFLX analogue, which was considerably less toxic than three reference quinolones (1, CPFX, and OFLX).

Pyridone carboxylic acid derivatives and salts thereof, process for producing the same and antibacterial agents comprising the same

This invention relates to a novel pyridone carboxylic acid derivative having a substituted or unsubstituted cyclopropyl group at the 10-position of pyridobenzoxazine, pyridobenzothiazine or pyridoquinoxaline and a salt thereof, a process for the productio