16676-75-8

Basic information

• Product Name: Vitamin E nicotinate
• Synonyms: tocopherylnicotinate,vitaminenicotinate;ALPHA-TOCOPHERYL NICOTINATE;[2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)CHROMAN-6-YL] PYRIDINE-3-CARBOXYLATE;(+/-)-2,5,7,8-Tetramethyl-2-(4,8,12 (-trimethyltridecyl)chromanol nicotinate;(+/-)-alpha-Tocopherol nicotinate;Vitamin E nicotinate;[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate;nicotin [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] ester
• CAS NO: 16676-75-8
• Molecular Formula: C35H53NO3
• Molecular Weight: 535.8
• EINECS: 257-501-4
• Mol File: 16676-75-8.mol

Chemical Properties

• Boiling Point: 649.02 °C at 760 mmHg
• Flash Point: 346.315 °C
• Appearance: /
• Density: 0.99 g/cm³
• Vapor Pressure: 9.93E-17mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Vitamin E nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Vitamin E nicotinate(16676-75-8)
• EPA Substance Registry System: Vitamin E nicotinate(16676-75-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 16676-75-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Vitamin E nicotinate is used as a cardiovascular agent for its potential to improve blood flow and circulation, supporting the treatment of certain cardiovascular conditions due to its vasodilatory effects.
Used in Dermatological Applications:
In dermatology, Vitamin E nicotinate is utilized as a therapeutic agent to alleviate inflammation and protect the skin from oxidative damage, making it beneficial for the treatment of various skin conditions.
Used in Skincare Industry:
Vitamin E nicotinate is employed as an active ingredient in skincare products for its antioxidant properties, which help maintain skin health and combat the signs of aging caused by free radicals.
Used in Dietary Supplements:
As a component of dietary supplements, Vitamin E nicotinate is used to provide the body with essential nutrients that support overall health, particularly focusing on the maintenance of a healthy cardiovascular system and skin.

InChI:InChI=1/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35+/m1/s1

Upstream product

• 59-67-6 nicotinic acid 
• 59-02-9 vitamin E 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 500-22-1 3-pyridinecarboxaldehyde 
• 59-02-9 Tocopherol 
• 73041-93-7 tosyl nicotinate 
• 59-02-9 (SRR/RSS)-α-tocopherol 

Relevant articles and documents

Synthesis method of tocopherol nicotinate

The invention belongs to the technical field of organic chemical synthesis, and relates to a method for preparing tocopherol nicotinate from 3-pyridylaldehyde and tocopherol. According to the method, 3-pyridylaldehyde and tocopherol are used as raw materials, N-heterocyclic carbene is used as a catalyst, and tocopherol nicotinate is synthesized through oxidative esterification. The method has the advantages of cheap raw materials, mild reaction conditions, simple process, greenness, safety, high efficiency and environmental protection, and is suitable for industrial production.

Highly selective trifluoromethylation of 1,3-disubstituted arenes through iridium-catalyzed arene borylation

The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. T

One-pot preparation of esters from carboxylic acids using the PPh3-CCl3CN system

A convenient one-pot process for preparing various esters from carboxylic acids using the Ph3P-CCl3CN has been developed. Racemic α-tocopherol, clofibrate and flavoxate were prepared in high yields using this method.

Cosmetic composition

Compositions containing an ester of nicotinic acid and a cosmetically acceptable surfactant are provided. These compositions, when applied topically to the human body produce a response such as a sensory or therapeutic response, for example a tingling or warming sensation or an increase in blood flow, which persists after the composition is rinsed from the body. The compositions are particularly suitable for application to the hair and/or scalp where they may encourage hair growth. Compositions for application to the hair and/or scalp preferably additionally comprise hair benefit agents such as hair growth promoters.