- Inhibitory effect of HT-1080 tumor cell invasion in vitro using 9-(2'-hydroxyethyl)adenine 2'-phosphates
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Several 9-(2'-hydroxyethyl)purine 2'-phosphates (2a-c and 3) showed a moderate inhibitory effect of tumor cell invasion using Matrigel. These 2'-phosphates (2a-c and 3) also inhibited the activity on type IV collagen degradation by matrix metalloprotease-9.
- Kitade, Yukio,Hayashi, Masa-Atsu,Yatome, Chizuko,Chajima, Masamitsu,Nagase, Hisamitsu
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- A method for preparation of adefovir dipivoxil
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The present invention discloses an adefovir dipivoxil preparation method, which comprises the following steps represented in the instruction. According to the present invention, base on the research of the existing adefovir dipivoxil synthesis route, the new synthesis route of 9-(2-hydroxyethyl)adenine is designed so as to provide the new method and the new idea for the synthesis of the drug adefovir dipivoxil, and provide help for the future drug development and production.
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- Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin
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Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the β-cyclodextrin cav
- Zhang, Qian,Cheng, Gang,Huang, Yong-Zhen,Qu, Gui-Rong,Niu, Hong-Ying,Guo, Hai-Ming
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experimental part
p. 7822 - 7826
(2012/09/22)
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- Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
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The malarial parasite Plasmodium falciparum (Pf) lacks the de novo pathway and relies on the salvage enzyme, hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), for the synthesis of the 6-oxopurine nucleoside monophosphates. Specific acyclic
- Hockova, Dana,Holy, Antonin,Masojidkova, Milena,Keough, Dianne T.,Jersey, John de,Guddat, Luke W.
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body text
p. 6218 - 6232
(2011/02/26)
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- Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)
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This paper describes studies carried out on a series of ATP analogues on the guinea pig bladder, a tissue reported to possess purinergic P2X-receptors.Optimisation of the pharmacological experimental technique enabled reproducible responses to ATP to be obtained in the 0.2-100 μM concentration range and the potencies of ATP analogues relative to ATP to be accurately determined.Alterations of the three main parts of the ATP molecule, i.e., the triphosphate, ribose and base, suggest that the triphosphate group is responsible for the efficacy of the agonist, whereas the ribose and adenine moieties are associated with affinity. quantitative analysis / ATP / purinergic / P2X-receptors / guinea pig bladder
- Howson, William,Taylor, Edwin Michael,Parsons, Michael Edward,Novelli, Riccardo,Wilczynska, Maria Aleksandra,Harris, Deborah Tracy
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p. 433 - 440
(2007/10/02)
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