1670-62-8

Basic information

• Product Name: 2-(6-Chloro-purin-9-yl)-ethanol
• Synonyms: 2-(6-Chloro-purin-9-yl)-ethanol
• CAS NO: 1670-62-8
• Molecular Formula: C₇H₇ClN₄O
• Molecular Weight: 198.60968
• Mol File: 1670-62-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 409.9 °C at 760 mmHg
• Flash Point: 201.7 °C
• Appearance: /
• Density: 1.65 g/cm³
• Vapor Pressure: 1.87E-07mmHg at 25°C
• Refractive Index: 1.739
• CAS DataBase Reference: 2-(6-Chloro-purin-9-yl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-Chloro-purin-9-yl)-ethanol(1670-62-8)
• EPA Substance Registry System: 2-(6-Chloro-purin-9-yl)-ethanol(1670-62-8)

Safety Data

• Hazardous Substances Data: 1670-62-8(Hazardous Substances Data)

Usage

General Description

"2-(6-Chloro-purin-9-yl)-ethanol" is a chemical compound that consists of a purine base with a chloro substituent attached to the 6th position and an ethanol group attached to the 2nd position. It is a derivative of the purine nucleoside adenosine and belongs to the class of purine analogs. 2-(6-Chloro-purin-9-yl)-ethanol has potential applications in medicinal chemistry, particularly in the development of antiviral and anticancer drugs. Its structure suggests that it may have biological activity as a nucleoside analog, potentially affecting various cellular processes. Further research and testing would be necessary to fully understand its potential uses and effects.

InChI:InChI=1/C7H7ClN4O/c8-6-5-7(10-3-9-6)12(1-2-13)4-11-5/h3-4,13H,1-2H2

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 6623-88-7 5-amino-6-chloro-4-(2'-hydroxyethylamino)pyrimidine 
• 96-49-1 [1,3]-dioxolan-2-one 
• 87-42-3 6-chloropurine 
• 56791-59-4 6-chloro-9-(ethoxycarbonylmethyl)-9H-purine 
• 540-51-2 2-bromoethanol 
• 107-07-3 2-chloro-ethanol 
• 87-42-3 6-chloro-1H-purine 

Downstream Products

• 707-99-3 9-(2-hydroxyethyl)adenine 
• 64127-00-0 6-Chlor-9-<2-chlor-aethyl>-purin 
• 1192066-31-1 C₁₄H₁₃ClN₄O₃S 
• 116384-53-3 [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester 
• 142340-99-6 adefovir dipivoxyl 
• 106941-25-7 Adefovir 

Relevant articles and documents

Inhibitory effect of HT-1080 tumor cell invasion in vitro using 9-(2'-hydroxyethyl)adenine 2'-phosphates

Several 9-(2'-hydroxyethyl)purine 2'-phosphates (2a-c and 3) showed a moderate inhibitory effect of tumor cell invasion using Matrigel. These 2'-phosphates (2a-c and 3) also inhibited the activity on type IV collagen degradation by matrix metalloprotease-9.

Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin

Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the β-cyclodextrin cav

Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)

This paper describes studies carried out on a series of ATP analogues on the guinea pig bladder, a tissue reported to possess purinergic P2X-receptors.Optimisation of the pharmacological experimental technique enabled reproducible responses to ATP to be obtained in the 0.2-100 μM concentration range and the potencies of ATP analogues relative to ATP to be accurately determined.Alterations of the three main parts of the ATP molecule, i.e., the triphosphate, ribose and base, suggest that the triphosphate group is responsible for the efficacy of the agonist, whereas the ribose and adenine moieties are associated with affinity. quantitative analysis / ATP / purinergic / P2X-receptors / guinea pig bladder