1670-62-8

Usage

Uses

Used in Medicinal Chemistry:
2-(6-Chloro-purin-9-yl)-ethanol is used as a precursor in the synthesis of antiviral and anticancer drugs due to its potential to interfere with cellular processes, making it a candidate for further research and development in pharmaceutical applications.
Used in Antiviral Drug Development:
In the field of antiviral research, 2-(6-Chloro-purin-9-yl)-ethanol is used as a chemical intermediate for creating new antiviral agents, leveraging its structure to target and inhibit viral replication mechanisms.
Used in Anticancer Drug Development:
2-(6-Chloro-purin-9-yl)-ethanol is utilized as a building block in the design of anticancer medications, with the aim of exploiting its purine analog properties to disrupt cancer cell metabolism or signaling pathways, thereby exhibiting anticancer activity.
Used in Biochemical Research:
2-(6-Chloro-purin-9-yl)-ethanol serves as a research tool in biochemical studies, helping scientists to understand the mechanisms of action of purine analogs and their interactions with biological systems, which is crucial for the advancement of medical knowledge and drug discovery.

InChI:InChI=1/C7H7ClN4O/c8-6-5-7(10-3-9-6)12(1-2-13)4-11-5/h3-4,13H,1-2H2

Upstream product

• 87-42-3 6-chloropurine 
• 56791-59-4 6-chloro-9-(ethoxycarbonylmethyl)-9H-purine 
• 540-51-2 2-bromoethanol 
• 107-07-3 2-chloro-ethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 87-42-3 6-chloro-1H-purine 
• 122-51-0 orthoformic acid triethyl ester 
• 6623-88-7 5-amino-6-chloro-4-(2'-hydroxyethylamino)pyrimidine 

Downstream Products

• 1192066-31-1 C₁₄H₁₃ClN₄O₃S 
• 116384-53-3 [[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester 
• 142340-99-6 adefovir dipivoxyl 
• 106941-25-7 Adefovir 
• 64127-00-0 6-Chlor-9-<2-chlor-aethyl>-purin 
• 707-99-3 9-(2-hydroxyethyl)adenine 

Relevant academic research and scientific papers

Inhibitory effect of HT-1080 tumor cell invasion in vitro using 9-(2'-hydroxyethyl)adenine 2'-phosphates

Several 9-(2'-hydroxyethyl)purine 2'-phosphates (2a-c and 3) showed a moderate inhibitory effect of tumor cell invasion using Matrigel. These 2'-phosphates (2a-c and 3) also inhibited the activity on type IV collagen degradation by matrix metalloprotease-9.

A method for preparation of adefovir dipivoxil

The present invention discloses an adefovir dipivoxil preparation method, which comprises the following steps represented in the instruction. According to the present invention, base on the research of the existing adefovir dipivoxil synthesis route, the new synthesis route of 9-(2-hydroxyethyl)adenine is designed so as to provide the new method and the new idea for the synthesis of the drug adefovir dipivoxil, and provide help for the future drug development and production.

Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin

Under the assistance of β-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the β-cyclodextrin cav

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

The malarial parasite Plasmodium falciparum (Pf) lacks the de novo pathway and relies on the salvage enzyme, hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), for the synthesis of the 6-oxopurine nucleoside monophosphates. Specific acyclic

Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)

This paper describes studies carried out on a series of ATP analogues on the guinea pig bladder, a tissue reported to possess purinergic P2X-receptors.Optimisation of the pharmacological experimental technique enabled reproducible responses to ATP to be obtained in the 0.2-100 μM concentration range and the potencies of ATP analogues relative to ATP to be accurately determined.Alterations of the three main parts of the ATP molecule, i.e., the triphosphate, ribose and base, suggest that the triphosphate group is responsible for the efficacy of the agonist, whereas the ribose and adenine moieties are associated with affinity. quantitative analysis / ATP / purinergic / P2X-receptors / guinea pig bladder