16874-12-7

Basic information

• Product Name: tert-Butyl L-tyrosinate
• Synonyms: tert-butyl l-tyrosinate;TYROSINE-OTBU;H-TYR-OBUT;H-TYR-OTBU;L-TYROSINE T-BUTYL ESTER;L-TYROSINE TERT-BUTYL ESTER;2-Amino-3-(4-hydroxy-phenyl)-propionic acid tert-butyl ester;Tyr-OtBu
• CAS NO: 16874-12-7
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.29
• EINECS: 240-902-3
• Product Categories: chiral;Miscellaneous;Amino Acids;Tyrosine [Tyr, Y];Amino Acids and Derivatives;Amino Acid tert-Butyl Esters;Amino Acids (C-Protected);Biochemistry;Amino ester;Amino Acid Derivatives;Amino Acids;I - ZPeptide Synthesis;Modified Amino Acids;Tyrosine
• Mol File: 16874-12-7.mol

Chemical Properties

• Melting Point: 141-144 °C
• Boiling Point: 358.1 °C at 760 mmHg
• Flash Point: 170.4 °C
• Appearance: White/Powder
• Density: 1.125 g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 25 ° (C=2, EtOH)
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 9.80±0.15(Predicted)
• BRN: 2696011
• CAS DataBase Reference: tert-Butyl L-tyrosinate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl L-tyrosinate(16874-12-7)
• EPA Substance Registry System: tert-Butyl L-tyrosinate(16874-12-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 16874-12-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
t-Butyl L-tyrosinate is used as a precursor for the synthesis of catecholamines, such as Norepinephrine HCl, which play a vital role in the human body's response to stress and are involved in various physiological processes. This application is particularly relevant in the development of treatments for conditions related to the sympathetic nervous system.
Used in Protein Synthesis:
t-Butyl L-tyrosinate is utilized as a building block in the synthesis of proteins, which are essential macromolecules that perform a wide range of functions in living organisms. The incorporation of this amino acid ester into proteins can contribute to their structure, stability, and function.
Used in Thyroid Hormone Synthesis:
t-Butyl L-tyrosinate is also used as a precursor in the production of thyroid hormones, which are critical for regulating metabolism, growth, and development in the human body. The synthesis of these hormones using t-Butyl L-tyrosinate can be beneficial in the treatment of thyroid-related disorders and maintaining overall health.
Used in Antioxidant and Antiradical Applications:
Due to its in vitro antioxidant and antiradical properties, t-Butyl L-tyrosinate can be employed in the development of compounds that protect cells from oxidative stress and damage. This application can be particularly useful in the fields of nutrition, cosmetics, and pharmaceuticals, where the prevention of oxidative damage is of significant importance.

InChI:InChI=1/C13H19NO3/c1-13(2,3)17-12(16)11(14)8-9-4-6-10(15)7-5-9/h4-7,11,15H,8,14H2,1-3H3/t11-/m0/s1

Upstream product

• 60-18-4 L-tyrosine 
• 115-11-7 isobutene 
• 16881-33-7 (S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate hydrate 
• 217172-40-2 (S)-2-amino-3-(4-benzyloxy-phenyl)-tert-butyl-propionic ester 
• 5544-60-5 4-(benzyloxy)benzyl bromide 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 1027921-22-7 2-(benzhydrylidene-amino)-3-(4-benzyloxy-phenyl)-propionic acid tert-butyl ester 
• 1164-16-5 Z-L-Tyr-OH 
• 540-88-5 acetic acid tert-butyl ester 
• 88878-78-8 tyrosine tert-butyl ester 
• 67-56-1 methanol 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 133852-23-0 tert-butyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate 

Downstream Products

• 18938-60-8 (S)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate 
• 100102-89-4 Z-Val-Tyr-OBu^t 
• 142822-20-6 N-benzyloxycarbonyl-L-seryl-L-tyrosine tert-butyl ester 
• 60-18-4 L-tyrosine 
• 179188-06-8 N-benzyltyrosine tert-butyl ester 
• 192822-99-4 N,N-dibenzyltyrosine tert-butyl ester 
• 133852-23-0 tert-butyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate 
• 178271-91-5 (S)-2-Benzyloxycarbonylamino-N-[(S)-1-tert-butoxycarbonyl-2-(4-hydroxy-phenyl)-ethyl]-succinamic acid benzyl ester 
• 216502-61-3 (S)-3-(4-Hydroxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester 
• 222976-52-5 2-tert-butoxycarbonylamino-N-[1-tert-butoxycarbonyl-2-(4-hydroxy-phenyl)-ethyl]-malonamic acid methyl ester 
• 185062-85-5 nitroveratryloxycarbonyl-L-tyrosine t-butyl ester 
• 221077-12-9 benzyl 4-{[(1S)-2-(tert-butoxy)-1-(4-hydroxybenzyl)-2-oxoethyl]amino}-4-oxobutanoate 
• 432515-20-3 (S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate 
• 432515-18-9 3-(4-hydroxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester 

Relevant articles and documents

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