169674-00-4

Basic information

• Product Name: 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester
• Synonyms: 1H-Indole-2-carboxylicacid, 6-chloro-5-fluoro-, ethyl ester;ethyl 6-chloro-5-fluoro-1H-indole-2-carboxylate;6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester;Methyl 6-chloro-5-fluoro-1H-indole-2-carboxylate;KITAYCDBMMPIMA-UHFFFAOYSA-N
• CAS NO: 169674-00-4
• Molecular Formula: C₁₁H₉ClFNO₂
• Molecular Weight: 241.648
• Mol File: 169674-00-4.mol

Chemical Properties

• Boiling Point: 380.6 °C at 760 mmHg
• Flash Point: 184 °C
• Appearance: /
• Density: 1.401
• Vapor Pressure: 5.39E-06mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester(169674-00-4)
• EPA Substance Registry System: 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester(169674-00-4)

Safety Data

• Hazardous Substances Data: 169674-00-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester is utilized as an intermediate in the synthesis of various pharmaceutical compounds. Its role in inhibiting PDK1 makes it a valuable component in the development of drugs targeting cancer treatment, where PDK1 inhibition can lead to the suppression of tumor growth and proliferation.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester is employed as an intermediate for the synthesis of agrochemicals. Its demonstrated activity against various bacterial strains suggests its potential use in developing new antibiotics or other antimicrobial agents to combat resistant bacteria in agricultural settings.
Used in Cancer Treatment Research:
6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester is being investigated for its potential therapeutic applications in cancer treatment. As a PDK1 inhibitor, it holds promise in the development of targeted therapies that could specifically address the uncontrolled cell growth characteristic of cancer.
Used in Antibiotic Development:
Given its activity against various strains of bacteria, 6-Chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester is a promising candidate for the development of new antibiotics. This is particularly relevant in the context of increasing antibiotic resistance, where novel compounds are urgently needed to combat resistant bacterial strains.

InChI:InChI=1/C11H9ClFNO2/c1-2-16-11(15)10-4-6-3-8(13)7(12)5-9(6)14-10/h3-5,14H,2H2,1H3

Upstream product

• 153500-78-8 ethyl 4-chloro-5-fluoro-1H-indole-2-carboxylate 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 175135-74-7 (3-chloro-4-fluorophenyl)hydrazine hydrochloride 
• 473258-19-4 Ethyl pyruvate 3-chloro-4-fluorophenylhydrazone 
• 84282-78-0 3-chloro-4-fluorophenyl hydrazine 

Relevant articles and documents

Indole derivative and medical application thereof

The invention discloses an indole compound with FABP4/5 inhibitory activity and a preparation method and medical application of the indole compound. The indole compound is a compound of which the structural formula is shown as a formula I, and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula I is a novel FABP4/5 inhibitor and can be used for preparing medicines for preventing or treating FABP4/5 related diseases.

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to antiviral agents. Specifically, the present invention relates to compounds of formula I which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for mating the compounds.

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: Role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity

Indolyl aryl sulfones bearing the 4,5-difluoro (10) or 5-chloro-4-fluoro (16) substitution pattern at the indole ring were potent inhibitors of HIV-1 WT and the NNRTI-resistant strains Y181C and K103N-Y181C. These compounds were highly effective against t