169674-01-5

Basic information

• Product Name: 5,6-Difluoroindole
• Synonyms: 5,6-DIFLUOROINDOLE;5,6-Difluoroindole98%;5,6-Difluoro-1H-indole;1H-Indole,5,6-difluoro-(9CI);1H-Indole,5,6-difluoro-
• CAS NO: 169674-01-5
• Molecular Formula: C₈H₅F₂N
• Molecular Weight: 153.13
• Product Categories: HALIDE;INDOLE;Indole/indoline/oxindole;Indole and Indoline;Indoles and derivatives;pharmacetical;Indoles;Boronic Acid;Heterocyclic Compounds
• Mol File: 169674-01-5.mol

Chemical Properties

• Boiling Point: 264.5 °C at 760 mmHg
• Flash Point: 113.8 °C
• Appearance: /
• Density: 1.388 g/cm³
• Vapor Pressure: 4.59E-08mmHg at 25°C
• Refractive Index: 1.661
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.56±0.30(Predicted)
• CAS DataBase Reference: 5,6-Difluoroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Difluoroindole(169674-01-5)
• EPA Substance Registry System: 5,6-Difluoroindole(169674-01-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 169674-01-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-White solid

InChI:InChI=1/C9H5F2NO2/c10-5-1-4-2-8(9(13)14)12-7(4)3-6(5)11/h1-3,12H,(H,13,14)

Upstream product

• 2927-34-6 3,4-difluorotoluene 
• 847685-02-3 (4,5-difluoro-2-iodo-phenyl)-carbamic acid methyl ester 
• 847685-01-2 2-iodo-4,5-difluoroaniline 
• 3863-11-4 3,4-difluoroaniline 
• 847685-03-4 (4,5-difluoro-2-trimethylsilanylethynyl-phenyl)-carbamic acid methyl ester 
• 468718-05-0 3,4-difluoro-5-nitrotoluene 

Downstream Products

• 260267-07-0 5,6-difluoro-1H-indole-3-carbaldehyde 

Relevant articles and documents

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The present invention relates to the use compounds of formula I which are antagonists of the 5-HT 6 receptor, for treating a cognitive disorder selected from the group consisting of age-related cognitive decline, mild cognitive impairment and dementia

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A highly convergent, scalable synthesis of the rebeccamycin analog 2 was demonstrated in seven steps and 31% overall yield based on the N-protected building block dibromomaleimide 7. The practical synthesis of other two building blocks, 5,6-difluoro-3-ben

Indole derivatives

The invention releates to indole derivatives of the formula STR1 wherein R 1 to R 4 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl or trifluoromethyl, R 5 and R 6 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl, trifluoromet