169772-25-2

Basic information

• Product Name: (tert-butylamino)(oxo)acetic acid
• Synonyms: (tert-butylamino)(oxo)acetic acid;acetic acid, [(1,1-dimethylethyl)amino]oxo-;Albb-009496;(tert-butylamino)(oxo)acetic acid(SALTDATA: FREE);2-(tert-butylamino)-2-keto-acetic acid;2-(tert-butylamino)-2-oxoacetic acid;2-(tert-butylamino)-2-oxo-acetic acid;2-(tert-butylamino)-2-oxo-ethanoic acid
• CAS NO: 169772-25-2
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Mol File: 169772-25-2.mol

Chemical Properties

• Appearance: /
• Density: 1.132g/cm³
• Refractive Index: 1.458
• CAS DataBase Reference: (tert-butylamino)(oxo)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (tert-butylamino)(oxo)acetic acid(169772-25-2)
• EPA Substance Registry System: (tert-butylamino)(oxo)acetic acid(169772-25-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 169772-25-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(tert-butylamino)(oxo)acetic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its steric hindrance and reactivity contribute to the development of complex molecular structures with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, (tert-butylamino)(oxo)acetic acid serves as a crucial component in the creation of effective and targeted agrochemicals. Its unique properties allow for the design of molecules with specific interactions and activities in agricultural settings.
Used in Organic Synthesis:
(tert-butylamino)(oxo)acetic acid is employed as a versatile building block in organic synthesis, enabling the construction of a wide range of complex molecules. Its steric hindrance and reactivity facilitate various chemical transformations and functionalization, expanding the scope of synthetic chemistry.
Used in Fine Chemicals Production:
(tert-butylamino)(oxo)acetic acid finds application in the production of fine chemicals, where its unique structural features are leveraged to create high-value specialty chemicals for diverse industries, including fragrances, dyes, and advanced materials.

InChI:InChI=1/C6H11NO3/c1-6(2,3)7-4(8)5(9)10/h1-3H3,(H,7,8)(H,9,10)

Upstream product

• 87034-69-3 N-tert-butyloxanillic acid ethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 
• 75-64-9 tert-butylamine 

Downstream Products

• 1609-86-5 Tert-butyl isocyanate 
• 37486-48-9 N,N'-di-tert-butyloxamide 
• 1040762-80-8 C₁₉H₁₆BrClF₃N₃O₃ 
• 5894-65-5 N-t-butylbenzamide 

Relevant articles and documents

Direct C3 Carbamoylation of 2H-Indazoles

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

Synthesis, crystal structure, and insecticidal activity of novel N-alkyloxyoxalyl derivatives of 2-arylpyrrole

Two series of novel N-alkyloxyoxalyl derivatives of 2-arylpyrrole were synthesized, and their structures were characterized by 1H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. The insecticidal activities of the new compounds were evaluated. The results of bioassays indicated that some of these title compounds exhibited excellent insecticidal activities, and their insecticidal activities against oriental armyworm, mosquito, and spider mite are comparable to those of the commercialized Chlorfenapyr.

Reactivity of Carbamoyl Radicals. A New, General, Convenient Free-Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid

A new, general, simple synthesis of isocyanates was developed by oxidation of monoamides of oxalix acid with peroxydisulfate catalyzed by Ag and Cu salts.The reaction was carried out in a two-phase system (water and an organic solvent), and it is suitable also for practical applications, due to the simple experimental conditions and the inexpensive as well as nontoxic reagents.The first example of homolytic intramolecular aromatic carbamoylation is also reported.