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2-(4-nitrobenzoyl)-N-phenylhydrazinecarbothioamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 17050-22-5 Structure
  • Basic information

    1. Product Name: 2-(4-nitrobenzoyl)-N-phenylhydrazinecarbothioamide
    2. Synonyms: 2-(4-nitrobenzoyl)-N-phenylhydrazinecarbothioamide;2-[(4-nitrophenyl)carbonyl]-N-phenylhydrazinecarbothioamide
    3. CAS NO:17050-22-5
    4. Molecular Formula: C14H12N4O3S
    5. Molecular Weight: 316.33508
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 17050-22-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(4-nitrobenzoyl)-N-phenylhydrazinecarbothioamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(4-nitrobenzoyl)-N-phenylhydrazinecarbothioamide(17050-22-5)
    11. EPA Substance Registry System: 2-(4-nitrobenzoyl)-N-phenylhydrazinecarbothioamide(17050-22-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 17050-22-5(Hazardous Substances Data)

17050-22-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 17050-22-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,5 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17050-22:
(7*1)+(6*7)+(5*0)+(4*5)+(3*0)+(2*2)+(1*2)=75
75 % 10 = 5
So 17050-22-5 is a valid CAS Registry Number.

17050-22-5Relevant articles and documents

Efficient and mild synthesis of substituted 2-amino-1,3,4-oxadiazoles mediated by (tosylimino)phenyl-γ3-iodane

Prabhu, Girish,Madhu, Chilakapathi,Sureshbabu, Vommina V.

, p. 865 - 870 (2014/08/05)

A simple and convenient one-pot protocol for the synthesis of substituted 2-amino-1,3,4-oxadiazoles mediated by (tosylimino)phenyl-γ3- iodane has been described. Acylthiosemicarbazides prepared from the corresponding acylhydrazides undergo effi

Synthesis of some 1,3,4-thiadiazole derivatives as inhibitors of Entamoeba histolytica

Siddiqui, Shadab Miyan,Salahuddin, Attar,Azam, Amir

, p. 1305 - 1312 (2013/04/10)

In the quest for potent anti-amoebic agents, some 1,3,4-thiadiazole derivatives were synthesized and characterized by spectral data. The purity of the compounds was confirmed by elemental analysis. All the compounds were screened in vitro against HM1:IMSS strain of Entamoeba histolytica by microdilution method. The results revealed that compounds 1 (IC50 = 0.670 μM), 3 (IC50 = 1.60 μM) and 8 (IC50 = 0.522 μM) had much better anti-amoebic activity than the reference drug metronidazole (IC50 = 1.80 μM). Further, cytotoxicity of the compounds having IC50 value less than metronidazole was assessed by MTT assay on human breast cancer MCF-7 cell line and all the compounds were found low cytotoxic in the concentration range of 2.5-250 μM. Preliminary results indicate that these three compounds (1, 3 and 8) may be subjected to further investigations and it may be hoped that the present study will stimulate efforts towards the development of novel effective anti-amoebic agents.

A one-pot synthesis of 4,5-disubstituted-1,2,4-triazole-3-thiones on solid support under microwave irradiation

Rostamizadeh, Shahnaz,Mollahoseini, Kambiz,Moghadasi, Samar

, p. 1839 - 1845 (2007/10/03)

4,5-Di-substituted-1,2,4-triazole-3-thiones (4a-f) have been prepared in one stage from the reaction of acid hydrazide 1 with alkyl or aryl isothiocyanate 2 in the presence of a KOH (10%) solution on the surface of silica gel as well as on the surface of montmorillonite K10 under microwave irradiation. These triazoles have also been prepared from the reaction of 4-substituted-1-aroyl thiosemicarbazides 3a-e, with a KOH (10%) solution on the surface of silica gel under microwave irradiation. Copyright Taylor & Francis Group, LLC.

Fragmentation and skeletal rearrangements of 2-arylylamino-5-aryl-1,3,4- oxadiazoles and their noncovalent complexes with cobalt cation and cyclodextrin studied by mass spectrometry

Franski, Rafal,Gierczyk, Blazej,Schroeder, Grzegorz

, p. 312 - 322 (2007/10/03)

Mass spectrometric fragmentation pathways of title compounds were studied by electron ionization (EI) and electrospray ionization (ESI) as methods of ion generation. To explain the observed complex skeletal rearrangements, tandem mass spectrometry, accurate mass measurement and isotope labeling (compounds containing one 13C atom in oxadiazole ring) were used. Loss of CO, N2 and H atoms under EI conditions led to the formation of 9,10-dihydroacridine-type ions, loss of NH3 under ESI conditions yielded the 4-phenylphthalazinone-type ions and the loss of HNCO under ESI conditions produced N-arylamino-benzonitrilium ions; however, this process can be affected by the electron-donor/electron-withdrawing properties of groups substituted at the phenyl rings. The ESI was used to study the complexes of the compounds with cobalt as well as with cyclodextrin. It was found that the compounds studied tend to form inclusion complexes with cyclodextrin of stoichiometry 1:1 and complexes of different stoichiometries with cobalt, although those of stoichiometry 6:1 and 4:1 are favored and the attachment of counter ion may stabilize the complexes 3:1 and 2:1. Copyright

The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

Baxendale, Ian R.,Ley, Steven V.,Martinelli, Marisa

, p. 5323 - 5349 (2007/10/03)

Herein, we report on the preparation of a library of 5-substituted-2-amino- 1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products.

Development of N-benzamidothioureas as a new generation of thiourea-based receptors for anion recognition and sensing

Nie, Li,Li, Zhao,Han, Jie,Zhang, Xuan,Yang, Rui,Liu, Wen-Xia,Wu, Fang-Ying,Xie, Jian-Wei,Zhao, Yu-Fen,Jiang, Yun-Bao

, p. 6449 - 6454 (2007/10/03)

A series of neutral N-(substituted-benzamido)-N′-phenylthioureas (substituent = p-OC2H5, p-CH3, m-CH 3, H, p-Cl, p-Br, m-Cl, and p-NO2) were designed as anion receptors, in which the thiourea binding site was attached to the benzamido moiety via an N-N bond. The absorption spectra of these N-benzamidothioureas in acetonitrile peaked at ca. 270 nm were found to show unprecedented red shifts by 7 373 to 14 325 cm-1 in the presence of anions such as AcO-, F-, and H2PO4-. Under the same conditions, the classic neutral thiourea receptors, N-(substituted-phenyl)-N′-phenylthioureas, showed absorption spectral shifts in most cases of less than 800 cm-1 with one exception of 6501 cm-1. Control experiments, effects of protic solvent, and 1H NMR titration confirmed the formation of hydrogen-bonding complexes between the new N-benzamidothiourea receptors and anions. The binding constants with AcO-, for example, are at 10 5-107 mol-1 L order of magnitude, which are 13 to 590 times those of the corresponding classic N-phenylthioureas in the same solvent. It was found that, whereas the absorption of the N-benzamidothiourea receptors showed essentially no dependence on the substituent, the substantially red-shifted new absorption band of the N-benzamidothiourea-anion binding complex was sensitively subject to the substituent. A linear relationship was found between the absorption energies of the N-benzamidothiourea-acetate binding complexes and the Hammett constants of the substituents with a negative slope of -0.34 eV. This led to the assignment that the substantially red-shifted absorption band was the ground-state intramolecular charge-transfer absorption with the substituent locating in the electron acceptor moiety. It was concluded that anion binding to the thiourea moiety of the N-benzamidothiourea receptors switched on their ground-state charge transfer. An anion-binding induced structural change was suggested to occur around the N-N bond in N-benzamidothioureas, which resulted in a substantially increased electron donating ability of the electron donor in the receptor molecules. As a consequence, the ground-state charge transfer takes place in the N-benzamidothiourea-anion binding complexes, leading to unprecedented red shifts in the absorption spectra and substantially enhanced anion binding affinities than those of the corresponding N-phenylthiourea receptors. N-Benzamido- N′-phenylthioureas represent a new generation of neutral thiourea-based anion receptors that show substantially improved anion binding performance important for anion sensing and recognition.

1,3,4-Thiadiazole derivatives. Synthesis, structure elucidation, and structure-antituberculosis activity relationship investigation

Oru?, El?in E.,Rollas, Sevim,Kandemirli, Fatma,Shvets, Nathaly,Dimoglo, Anatholy S.

, p. 6760 - 6767 (2007/10/03)

A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized, the compounds structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-(4-fluorophenyl) -1,3,4-thiadiazole 22 showed the highest inhibitory activity. The relationships between the structures of compounds and their antituberculosis activity were investigated by the Electronic-Topological Method (ETM) and feed forward neural networks (FFNNs) trained with the back-propagation algorithm. As a result of the approach, a system of pharmacophores and anti-pharmacophores has been found that effectively separates compounds of the examination set into groups of active and inactive compounds. The system can be applied to the screening and design of new active compounds possessing skeletons similar to those used in the present study.

Synthesis and characterization of palladium(II) complexes derived from aromatic thiosemicarbazide derivatives

Bekheit, M. M.,Elewady, Y. A.,Taha, F. I.,Mostafa, S. I.

, p. 178 - 183 (2007/10/02)

The reaction of aromatic thiosemicarbazides with palladium(II) ions give three type of complexes having the composition PdLCl2, Pd(L-H)2 and Pd(L-2H) .Elemental analyses, molar conductivities, magnetic measurements and spe

Efficiency of Some Phenylthiosemicarbazide Derivatives in Retarding the Dissolution of Al in NaOH Solution

Fouda, A. S.,Elasmy, A. A.

, p. 709 - 716 (2007/10/02)

Five derivatives of phenylthiosemicarbazide have been prepared and treated as inhibitors for the corrosion of aluminium in 2 M sodium hydroxide.All the five substances afford 98,5 to 75percent protection to aluminium in sodium hydroxide. 1-(Methoxybenzoyl

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