170861-45-7

Basic information

• Product Name: 2-Thiophenemethanol,3-amino-(9CI)
• Synonyms: 2-Thiophenemethanol,3-amino-(9CI);3-Amino-2-(hydroxymethyl)thiophene;3-amino-2-Thiophenemethanol
• CAS NO: 170861-45-7
• Molecular Formula: C₅H₇NOS
• Molecular Weight: 129.182
• Product Categories: AMINEPRIMARY
• Mol File: 170861-45-7.mol

Chemical Properties

• Boiling Point: 347.6°C at 760 mmHg
• Flash Point: 164°C
• Appearance: /
• Density: 1.359g/cm³
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.665
• PKA: 13.75±0.10(Predicted)
• CAS DataBase Reference: 2-Thiophenemethanol,3-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenemethanol,3-amino-(9CI)(170861-45-7)
• EPA Substance Registry System: 2-Thiophenemethanol,3-amino-(9CI)(170861-45-7)

Safety Data

• Hazardous Substances Data: 170861-45-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Chemical Industries:
2-Thiophenemethanol,3-amino-(9CI) serves as a key building block in the synthesis of various pharmaceuticals and bioactive molecules. Its presence in these industries is attributed to the versatility of the amino group, which can engage in a range of chemical reactions, facilitating the development of new drugs and bioactive compounds.
Used in Organic Synthesis:
In the realm of organic synthesis, 2-Thiophenemethanol,3-amino-(9CI) is utilized for its capacity to participate in multiple chemical reactions, contributing to the formation of complex organic molecules. The thiophene ring's unique aromatic and electronic characteristics enhance the compound's utility in this field.
Used in Medicinal Chemistry:
2-Thiophenemethanol,3-amino-(9CI) is also employed in medicinal chemistry, where its structural features are leveraged to design and develop novel therapeutic agents. 2-Thiophenemethanol,3-amino-(9CI)'s ability to be modified and incorporated into larger molecular frameworks makes it instrumental in the advancement of drug discovery and the creation of bioactive molecules with potential therapeutic applications.

InChI:InChI=1/C5H7NOS/c6-4-1-2-8-5(4)3-7/h1-2,7H,3,6H2

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 

Downstream Products

• 56473-92-8 thieno[3,2-b]pyridine-5-carboxylic acid 
• 1613505-79-5 C₁₅H₁₅NO₃S₂ 
• 1613505-61-5 C₂₂H₁₇NO₃S₂ 
• 1262031-34-4 C₁₃H₁₃NO₂S 

Relevant articles and documents

BICYCLIC HETEROAROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes bicyclic heteroaromatic carboxamide derivatives of formula (I), as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

Cyclisation reactions of some pyridazinylimidoylketenes

Flash vacuum pyrolysis (FVP) of aminopyridazinone derivatives of Meldrum's acid at 600 °C (0.02 Torr) results in generation of an imidoylketene intermediate followed by cyclisation. In the case of the 5-amino derivatives, the products are pyrido[2,3-d]pyridazines, whereas the 4-amino compounds lead to mixtures of pyrido[2,3-d]pyridazines and pyrrolo[3,2-c]pyridazines. The feasibility of the 1,5-sigmatropic shift of a chlorine atom, required for the formation of two of the pyrido[2,3-d]pyridazines, was supported by the corresponding reaction of a corresponding 2,6-dichloroaniline derivative. The feasibility of the decarboxylation mechanism required for the formation of the pyrrolo[3,2-c]pyridazines, was supported by related processes in the FVP reactions of model compounds and by DFT calculations.

HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF

This invention relates to known and novel hydroxyquinolin-2(1H)-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also relates to pharmaceutical compositions containing such compounds.

DIARYL 5,6-FUSED HETEROCYCLIC ACIDS AS LEUKOTRIENE ANTAGONISTS

Compounds having the formula I: STR1 are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.