170941-79-4Relevant articles and documents
Sol and gel states in peptide hydrogels visualized by Gd(III)-enhanced magnetic resonance imaging
Weerasekare, Mahika,Taraban, Marc B.,Shi, Xianfeng,Jeong, Eun-Kee,Trewhella, Jill,Yu, Yihua Bruce
, p. 734 - 743 (2011)
The hydrogels assembled from a pair of self-repulsive but mutually attractive decapeptides are visualized by magnetic resonance imaging (MRI). It is found that in the absence of Gd(III)-chelate, gelation has little effect on MRI signal intensity. In the presence of Gd(III)-chelate, gelation leads to significant changes in water relaxation and MR signal intensity. The sol to gel transition is best visualized by T2-weighted imaging using large echo time with the sol producing a bright spot and the gel producing a dark spot. MRI studies point to high local Gd(III)-chelate concentration. Small-angle X-ray scattering study indicates that this local enrichment of Gd(III)-chelate has two contributing processes: first, the aggregation of peptides into fibers; second, within peptide fibers, Gd(III)- chelate further aggregate into clusters. This work demonstrates that the status of peptide-based hydrogels can be visualized by MRI with the aid of covalently linked Gd(III)-chelates. This result has implications for monitoring peptide scaffolds in vivo.
Peptides and synthetic cell membranes
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, (2008/06/13)
Linear peptides of the formula (I) R-A-B-C-D-E-OH, where R, A, B, C, D and E have the indicated meanings, are disclosed. Methods of making these peptides, and of using them as biosensors, solar cells and membrane models for use in the investigation of biochemical processes are disclosed.
