- SOME ANALOGS OF 4-(2',4'-DIFLUOROBIPHENYL-4-YL)-2-METHYL-4-OXOBUTANOIC ACID: SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY
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Analogs of 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (I, flobufen), containing a double bond (II, IV, V, VII, VIII) or a methyl group in position 3 (VI) were prepared.Their antiinflammatory activity was evaluated and compared with that of flobufen.None of the mentioned analogs reached the activity of the standard.Isomerization of the unsaturated derivatives is connected with a shift of the double bond, Z-E transformation or lactonization.Reaction conditions and spectra of the compounds prepared are described.
- Kuchar, Miroslav,Vosatka, Vaclav,Poppova, Marie,Knezova, Eva,Panajotovova, Vladimira,et al.
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p. 1026 - 1033
(2007/10/03)
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