17117-19-0

Basic information

• Product Name: 3-Bromo-2,5-lutidine
• Synonyms: 3-Bromo-2,5-dimethylpyridine;3-Bromo-2,5-lutidine
• CAS NO: 17117-19-0
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.04912
• Product Categories: Pyridines
• Mol File: 17117-19-0.mol

Chemical Properties

• Boiling Point: 207℃
• Flash Point: 79℃
• Appearance: /
• Density: 1.415
• Vapor Pressure: 0.339mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• PKA: 3.89±0.20(Predicted)
• CAS DataBase Reference: 3-Bromo-2,5-lutidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2,5-lutidine(17117-19-0)
• EPA Substance Registry System: 3-Bromo-2,5-lutidine(17117-19-0)

Safety Data

• Hazardous Substances Data: 17117-19-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Bromo-2,5-lutidine is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides. Its unique chemical properties allow it to be a valuable building block in the creation of these compounds.
Used in Dye Production:
3-Bromo-2,5-lutidine is utilized as a crucial component in the production of dyes, where its chemical structure plays a significant role in determining the color and properties of the final product. Its use in this industry helps in the development of a wide range of dyes with specific characteristics.
Used in Metallurgical Additive Industry:
In the metallurgical additive industry, 3-Bromo-2,5-lutidine is employed as an additive to enhance the properties of metals. Its incorporation into metallurgical processes can improve the performance and characteristics of various metal alloys.
Used in Organic Synthesis:
3-Bromo-2,5-lutidine is used as a building block in organic synthesis, where it serves as a starting material for the production of a variety of fine chemicals. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Research and Academic Laboratories:
3-Bromo-2,5-lutidine is also found in research and academic laboratories as a reagent in organic chemistry reactions. Its unique properties make it a useful tool for chemists in conducting various experiments and exploring new chemical reactions.
However, it is essential to handle 3-Bromo-2,5-lutidine with caution due to its flammable nature and potential to cause irritation to the skin, eyes, and respiratory system upon exposure. Proper safety measures should be taken to minimize any risks associated with its use.

InChI:InChI=1/C7H8BrN/c1-5-3-7(8)6(2)9-4-5/h3-4H,1-2H3

Upstream product

• 89943-02-2 2,5-dimethyl-3-aminopyridine 
• 1211533-93-5 2-methyl-3-nitro-5-chloropyridine 
• 589-93-5 2,5-dimethylpyridine 

Downstream Products

• 1029654-18-9 C₇H₁₀BNO₂ 

Relevant articles and documents

Synthesis method of 2, 5-dimethyl-3-bromopyridine

The invention relates to the field of organic chemistry, in particular to a synthesis method of 2, 5-dimethyl-3-bromopyridine. The synthesis method comprises the following steps: 1, reacting diethyl malonate with an alkali metal to generate a salt, dropwisely adding a toluene solution of 2 methyl-3-nitro-5-chloropyridine to perform condensation reaction, and decarboxylating under acidic conditionsto obtain 2, 5-dimethyl-3-nitropyridine; 2, carrying out hydrogenation reduction, suction filtration and filtrate concentration on the obtained 2, 5-dimethyl-3-nitropyridine by taking methanol as a solvent under the catalysis of Pd/C so as to obtain 2, 5-dimethyl-3-aminopyridine;, and 3, reacting the obtained 2, 5-dimethyl-3-aminopyridine with an acid to generate a salt, cooling to -9 DEG C to 4DEG C, dropwise adding liquid bromine, dropwise adding a sodium nitrite aqueous solution after dropwise adding of liquid bromine, adjusting the pH value of an obtained solution to be higher than 7 after dropwise adding of the sodium nitrite aqueous solution, and then extracting, drying and concentrating to obtain 2, 5-dimethyl-3-bromopyridine. The method provided by the invention has the beneficial effects of mild reaction conditions, high yield, easily available raw materials, low cost, short process route and an industrial prospect.

A 2, 5 - dimethyl -3 - bromo pyridine synthesis method

The invention relates to the field of organic chemistry, in particular to a 2, 5 - dimethyl - 3 - bromo pyridine synthesis method, comprises the following steps: 1, malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 2 methyl - 3 - nitro - 5 chloro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions shall be 2, 5 - dimethyl - 3 - nitro pyridine; 2, 2, 5 - dimethyl - 3 - nitro pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, shall be 2, 5 - dimethyl - 3 - aminopyridine; 3, 2, 5 - dimethyl - 3 - aminopyridine first with an acid generating salt, cooling to - 9 °C - 4 °C, [...], drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, shall be 2, 5 - dimethyl - 3 - bromo pyridine. The method of the invention is beneficial effect: mild reaction conditions, high yield, and raw materials are easy, and the cost is low, the process route is short, and has industrial prospects.

A 2, 5 - dimethyl - 3 - bromo pyridine synthesis method (by machine translation)

The invention relates to the field of organic chemistry, in particular to a 2, 5 - dimethyl - 3 - bromo pyridine synthesis method, comprises the following steps: 1, malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 2 methyl - 3 - nitro - 5 chloro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions shall be 2, 5 - dimethyl - 3 - nitro pyridine; 2, 2, 5 - dimethyl - 3 - nitro pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, shall be 2, 5 - dimethyl - 3 - aminopyridine; 3, 2, 5 - dimethyl - 3 - aminopyridine first with an acid generating salt, cooling to - 9 °C - 4 °C, instillment fluid bromine, drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, shall be 2, 5 - dimethyl - 3 - bromo pyridine. The method of the invention is beneficial effect: mild reaction conditions, high yield, and raw materials are easy, and the cost is low, the process route is short, and has industrial prospects. (by machine translation)