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2,5-diMethylpyridin-3-aMine, also known as 2,5-Dimethyl-3-pyridinamine, is an organic compound with the chemical formula C7H10N2. It is a white crystalline solid and is used as a general reagent in the synthesis of various pharmaceuticals.

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  • 89943-02-2 Structure
  • Basic information

    1. Product Name: 2,5-diMethylpyridin-3-aMine
    2. Synonyms: 2,5-diMethylpyridin-3-aMine;2,5-DiMethyl-pyridin-3-ylaMine;2,5-dimethyl-3-Pyridinamine
    3. CAS NO:89943-02-2
    4. Molecular Formula: C7H10N2
    5. Molecular Weight: 122.1677
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 89943-02-2.mol
  • Chemical Properties

    1. Melting Point: 79-80 °C
    2. Boiling Point: 254.3±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.039±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 7.18±0.20(Predicted)
    10. CAS DataBase Reference: 2,5-diMethylpyridin-3-aMine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,5-diMethylpyridin-3-aMine(89943-02-2)
    12. EPA Substance Registry System: 2,5-diMethylpyridin-3-aMine(89943-02-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 89943-02-2(Hazardous Substances Data)

89943-02-2 Usage

Uses

Used in Pharmaceutical Industry:
2,5-diMethylpyridin-3-aMine is used as a general reagent for the synthesis of pharmaceuticals such as CCR9 and CCR10 modulators. It plays a crucial role in the development of these drugs, which have potential applications in the treatment of various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 89943-02-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,9,4 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 89943-02:
(7*8)+(6*9)+(5*9)+(4*4)+(3*3)+(2*0)+(1*2)=182
182 % 10 = 2
So 89943-02-2 is a valid CAS Registry Number.

89943-02-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-dimethylpyridin-3-amine

1.2 Other means of identification

Product number -
Other names 2,5-LUTIDINE,3-AMINO

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89943-02-2 SDS

89943-02-2Relevant articles and documents

(PYRIDIN-2-YL)AMINE DERIVATIVES AS TGF-BETA R1 (ALK5) INHIBITORS FOR THE TREATMENT OF CANCER

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, (2020/07/15)

The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder associated with ΤGFβR1 activity, such as a cancer or fibrosis. The invention provides compounds of Formula (I) and Formula (II) as further described herein having an acidic moiety that enhances tissue specificity for targeted tissues and organs. The invention includes pharmaceutical compositions, pharmaceutical combinations, and methods of use of these compounds for treating conditions including cancer or fibrosis.

Synthesis method of 2, 5-dimethyl-3-bromopyridine

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, (2020/03/09)

The invention relates to the field of organic chemistry, in particular to a synthesis method of 2, 5-dimethyl-3-bromopyridine. The synthesis method comprises the following steps: 1, reacting diethyl malonate with an alkali metal to generate a salt, dropwisely adding a toluene solution of 2 methyl-3-nitro-5-chloropyridine to perform condensation reaction, and decarboxylating under acidic conditionsto obtain 2, 5-dimethyl-3-nitropyridine; 2, carrying out hydrogenation reduction, suction filtration and filtrate concentration on the obtained 2, 5-dimethyl-3-nitropyridine by taking methanol as a solvent under the catalysis of Pd/C so as to obtain 2, 5-dimethyl-3-aminopyridine;, and 3, reacting the obtained 2, 5-dimethyl-3-aminopyridine with an acid to generate a salt, cooling to -9 DEG C to 4DEG C, dropwise adding liquid bromine, dropwise adding a sodium nitrite aqueous solution after dropwise adding of liquid bromine, adjusting the pH value of an obtained solution to be higher than 7 after dropwise adding of the sodium nitrite aqueous solution, and then extracting, drying and concentrating to obtain 2, 5-dimethyl-3-bromopyridine. The method provided by the invention has the beneficial effects of mild reaction conditions, high yield, easily available raw materials, low cost, short process route and an industrial prospect.

A 2, 5 - dimethyl -3 - bromo pyridine synthesis method

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, (2019/05/28)

The invention relates to the field of organic chemistry, in particular to a 2, 5 - dimethyl - 3 - bromo pyridine synthesis method, comprises the following steps: 1, malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 2 methyl - 3 - nitro - 5 chloro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions shall be 2, 5 - dimethyl - 3 - nitro pyridine; 2, 2, 5 - dimethyl - 3 - nitro pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, shall be 2, 5 - dimethyl - 3 - aminopyridine; 3, 2, 5 - dimethyl - 3 - aminopyridine first with an acid generating salt, cooling to - 9 °C - 4 °C, [...], drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, shall be 2, 5 - dimethyl - 3 - bromo pyridine. The method of the invention is beneficial effect: mild reaction conditions, high yield, and raw materials are easy, and the cost is low, the process route is short, and has industrial prospects.

FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS

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Page/Page column 60, (2018/04/11)

Novel fused pyrazole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

A 2, 5 - dimethyl - 3 - bromo pyridine synthesis method (by machine translation)

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, (2017/09/26)

The invention relates to the field of organic chemistry, in particular to a 2, 5 - dimethyl - 3 - bromo pyridine synthesis method, comprises the following steps: 1, malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 2 methyl - 3 - nitro - 5 chloro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions shall be 2, 5 - dimethyl - 3 - nitro pyridine; 2, 2, 5 - dimethyl - 3 - nitro pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, shall be 2, 5 - dimethyl - 3 - aminopyridine; 3, 2, 5 - dimethyl - 3 - aminopyridine first with an acid generating salt, cooling to - 9 °C - 4 °C, instillment fluid bromine, drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, shall be 2, 5 - dimethyl - 3 - bromo pyridine. The method of the invention is beneficial effect: mild reaction conditions, high yield, and raw materials are easy, and the cost is low, the process route is short, and has industrial prospects. (by machine translation)

PYRIDYLAMIDINE COMPOUND OR SALT THEREOF, AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT

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Page/Page column 17, (2009/09/04)

An agricultural or horticultural fungicide composition having stabilized high plant disease control effect is provided. The agricultural or horticultural fungicide composition contains a pyridylamidine compound represented by the formula (I): or a salt th

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