171349-99-8

Basic information

• Product Name: N-Ethyl-N-(4-phenoxyphenyl)amine
• Synonyms: N-Ethyl-N-(4-phenoxyphenyl)amine
• CAS NO: 171349-99-8
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.275
• Mol File: 171349-99-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Ethyl-N-(4-phenoxyphenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl-N-(4-phenoxyphenyl)amine(171349-99-8)
• EPA Substance Registry System: N-Ethyl-N-(4-phenoxyphenyl)amine(171349-99-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 171349-99-8(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 139-59-3 4-phenoxyanilin 
• 6312-87-4 p-phenoxyacetanilide 

Relevant articles and documents

Homogeneous cobalt-catalyzed deoxygenative hydrogenation of amides to amines

The first general and efficient cobalt-catalyzed deoxygenative hydrogenation of amides to amines is presented. The optimal catalytic system based on a combination of [Co(NTf2)2] and (p-anisyl)triphos (L3) in the presence of [Me3SiOTf] as acidic co-catalyst facilitates the direct hydrogenation of a broad range of amides to the corresponding amines under mild conditions. A set of control experiments indicate that, after the initial reduction of the amide carboxylic group to the well-known hemiaminal intermediate, the reaction mainly proceeds through C-O bond cleavage though other pathways might be also involved to a minor extent. This journal is

Tailored Cobalt-Catalysts for Reductive Alkylation of Anilines with Carboxylic Acids under Mild Conditions

The first cobalt-catalyzed hydrogenative N-methylation and alkylation of amines with readily available carboxylic acid feedstocks as alkylating agents and H2 as ideal reductant is described. Combination of tailor-made triphos ligands with cobalt(II) tetrafluoroborate significantly improved the efficiency, thus promoting the reaction under milder conditions. This novel protocol allows for a broad substrate scope with good functional group tolerance, even in the presence of reducible alkenes, esters, and amides.

Catalytic N-Alkylation of Amines Using Carboxylic Acids and Molecular Hydrogen

A convenient, practical and green N-alkylation of amines has been accomplished by applying readily available carboxylic acids in the presence of molecular hydrogen. Applying an in situ formed ruthenium/triphos complex and an organic acid as cocatalyst, a broad range of alkylated secondary and tertiary amines are obtained in good to excellent yields. This novel method is also successfully applied for the synthesis of unsymmetrically substituted N-methyl/alkyl anilines through a direct three-component coupling reaction of the corresponding amines, carboxylic acids, and CO2 as a C1 source.