6312-87-4

Basic information

• Product Name: N-(4-PHENOXY-PHENYL)-ACETAMIDE
• Synonyms: N-(4-PHENOXY-PHENYL)-ACETAMIDE;Ccris 7394;N-(4-Phenoxyphenyl)
• CAS NO: 6312-87-4
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.25852
• Mol File: 6312-87-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: 106-107 °C
• Boiling Point: 410.8 °C at 760 mmHg
• Flash Point: 202.2 °C
• Appearance: /
• Density: 1.176 g/cm³
• Vapor Pressure: 5.87E-07mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.36±0.70(Predicted)
• CAS DataBase Reference: N-(4-PHENOXY-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-PHENOXY-PHENYL)-ACETAMIDE(6312-87-4)
• EPA Substance Registry System: N-(4-PHENOXY-PHENYL)-ACETAMIDE(6312-87-4)

Safety Data

• Hazardous Substances Data: 6312-87-4(Hazardous Substances Data)

Usage

General Description

N-(4-phenoxy-phenyl)-acetamide is a chemical compound with the molecular formula C14H13NO2. It is an amide derivative with a phenyl group substituted at the 4-position of the phenoxy group. N-(4-PHENOXY-PHENYL)-ACETAMIDE is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of other organic molecules. It may also have potential biological activities and is being investigated for its potential use in medicinal chemistry. Additionally, it is important to handle this compound with care as it may have certain hazards associated with its handling and use.

InChI:InChI=1/C14H13NO2/c1-11(16)15-12-7-9-14(10-8-12)17-13-5-3-2-4-6-13/h2-10H,1H3,(H,15,16)

Upstream product

• 5031-78-7 4-phenoxyacetophenone 
• 620-88-2 4-nitrophenyl phenyl ether 
• 64-19-7 acetic acid 
• 6337-25-3 1-(4-phenoxy-phenyl)-ethanone oxime 
• 139-59-3 4-phenoxyanilin 
• 108-24-7 acetic anhydride 
• 6341-97-5 1,3-dichloro-4-acetoxybenzene 
• 103-88-8 4-bromoacetanilide 
• 108-95-2 phenol 
• 108-86-1 bromobenzene 
• 103-90-2 4-acetaminophenol 
• 591-50-4 iodobenzene 
• 75-05-8 acetonitrile 
• 14040-11-0 tungsten hexacarbonyl 

Downstream Products

• 860578-02-5 acetic acid-[4-(4-iodo-phenoxy)-anilide] 
• 876496-63-8 N-[4-(4-bromophenoxy)phenyl]acetamide 
• 855837-35-3 6-phenoxy-[8]quinolylamine 
• 855761-40-9 8-nitro-6-phenoxy-quinoline 
• 315248-48-7 N-acetyl-sulfanilic acid-(4-phenoxy-anilide) 
• 139-59-3 4-phenoxyanilin 
• 171349-99-8 N-ethyl-4-phenoxyaniline 
• 1120334-11-3 2-bromo-6-nitro-4-phenoxyphenylamine 
• 1613336-62-1 3,5-diiodo-2-methoxy-N-methyl-N-(4-phenoxyphenyl)benzamide 
• 1613336-61-0 2-hydroxy-3,5-diiodo-N-methyl-N-(4-phenoxyphenyl)benzamide 
• 72920-03-7 para-phenoxy-N-methylaniline 
• 92163-23-0 2-methyl-6-phenoxy-benzothiazole 
• 58518-73-3 4-(4-iodo-phenoxy)-aniline 

Relevant articles and documents

A novel construction of acetamides from rhodium-catalyzed aminocarbonylation of DMC with nitro compounds

Dimethyl carbonate (DMC), an environment-friendly compound prepared from CO2, shows diverse reactivities. In this communication, an efficient procedure using DMC as both a C1 building block and solvent in the aminocarbonylation reaction with nitro compounds has been developed. W(CO)6acts both a CO source and a reductant here.

Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors

A new series of quinoline-chalcone hybrids was synthesized. The structures of these compounds were characterized by spectroscopic methods including 1H and 13CNMR and mass spectroscopy. The cytotoxic activity of compounds was evaluated against four human cancer cell lines including A2780 (human ovarian carcinoma) and A2780/RCIS (Cisplatin resistant human ovarian carcinoma), MCF-7 (human breast cancer cells), MCF-7/MX (Mitoxantrone resistant human breast cancer cells) and normal Huvec cells. The structure-activity relationship of synthesized compounds is discussed. Among quinolines 5e, 5g and 5j possessing benzoyl group showed significant cytotoxic activity against both resistant cancer cells and their parents. Compounds 5g and 5j, demonstrated the most antiproliferative activity with IC50 values ranging from 2.32 to 22.4 μM. They were also identified as tubulin inhibitors and induced cell cycle arrest at G2/M phase and apoptosis. Compound 5j induced more arrest at G2/M phase in four cancer cell lines compared to compound 5g. Finally, molecular dynamics simulation and molecular docking studies of compound 5j into the colchicine-binding site of tubulin demonstrated the possible interaction of this compound in the active site of tubulin.

Visible-light-induced Beckmann rearrangement by organic photoredox catalysis

A facile and general strategy for efficient direct conversion of oximes to amides using an inexpensive organic photocatalyst and visible light is described. This radical Beckmann rearrangement can be performed under mild conditions. Various alkyl aryl ketoximes and diaryl ketoximes can be effectively converted into the corresponding amides in excellent yields.