17183-98-1

Basic information

• Product Name: (1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione
• Synonyms: 6-Chloro-1alpha-(chloromethyl)-17-hydroxypregna-4,6-diene-3,20-dione acetate;Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro-1-(chloromethyl)-, (1a)-;6-chioro-1α-chloromethyl-3,20-dioxo-pregna-4,6-dien-17α-acetoxy;1-CHLOROMETHYL-6-CHLORO-6-DEHYDRO-17ACETOXY PROGESTRONE;(1S,8R,9S,10S,13S,14S,17R)-17-acetyl-6-chloro-1-(chloroMethyl)-10,13-diMethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate;(1alpha)-17-(Acetyloxy)-6-chloro-1-(chloroMethyl)prehna-4,6-diene-3,20-dione;Color Pronk chloride;1-ChlormehylL-6-Chloro-6-Dehydro- 17α-Acetoxy-Progesterone
• CAS NO: 17183-98-1
• Molecular Formula: C₂₄H₃₀Cl₂O₄
• Molecular Weight: 453.4
• EINECS: 1308068-626-2
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 17183-98-1.mol

Chemical Properties

• Boiling Point: 554.4 °C at 760 mmHg
• Flash Point: 181.7 °C
• Appearance: /
• Density: 1.27
• Vapor Pressure: 0-0Pa at 20-30℃
• Refractive Index: 1.564
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: (1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione(17183-98-1)
• EPA Substance Registry System: (1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione(17183-98-1)

Safety Data

• Hazardous Substances Data: 17183-98-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione is used as an impurity in the production of Cyproterone acetate (C989100) for its antiandrogenic steroid properties. Cyproterone acetate is a medication that is used to treat various conditions related to androgen excess, such as hirsutism, acne, and prostate cancer. The presence of (1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione as an impurity ensures the quality and efficacy of the final drug product.
Used in Research and Development:
(1alpha)-17-(Acetyloxy)-6-chloro-1-(chloromethyl)pregna-4,6-diene-3,20-dione can also be used as a research compound in the development of new drugs and therapies. Its unique structure and properties make it a valuable tool for studying the effects of steroidal compounds on various biological systems and for identifying potential targets for drug action.

InChI:InChI=1/C24H30Cl2O4/c1-13(27)24(30-14(2)28)8-6-18-17-11-21(26)20-10-16(29)9-15(12-25)23(20,4)19(17)5-7-22(18,24)3/h10-11,15,17-19H,5-9,12H2,1-4H3/t15-,17+,18+,19+,22+,23-,24+/m1/s1

Upstream product

• 2701-50-0 1,2α-methylene-Δ4,6-pregnadiene-17α-ol-3,20-dione-17-acetate 
• 2098-65-9 17α-hydroxy-1α,2α-methylene-4,6-pregnadiene-3,20-dione 
• 66212-25-7 1,4,6-triene-3,20-dione-17α-hydroxyprogesterone 
• 15423-97-9 1,2α-methylene-6,7α-oxido-Δ4-pregnen-17α-ol-3,20-dione-17-acetate 

Downstream Products

• 427-51-0 cyproterone acetate 

Relevant articles and documents

Preparation process of cyproterone acetate (by machine translation)

The invention relates to a preparation process of cyproterone acetate, which comprises the following steps: ketal reaction; cyclopropanecarboxylic hydrolysis reaction; acetyl reaction; epoxy reaction; chlorinated reaction; a cyclization reaction; the invention can overcome the original process product is difficult to solve in the benzene remains the problem of, and the start is simple in raw material, reaction is stable, the total yield is high. (by machine translation)

Further syntheses of cyproterone acetate

The present invention relates to improved methods for synthesising cyproterone acetate (17α-Acetoxy-6-chloro-1α, 2α-methylene-4,6-pregnadiene-3,20-dione) from solasodine. The methods of the invention are shorter as those of the prior art and therefore more economic.