15423-97-9

Usage

Uses

Used in Pharmaceutical Industry:
6-Deschloro-6,7-epoxy Cyproterone Acetate is used as an impurity in the production of Cyproterone acetate for pharmaceutical applications. As an impurity, it is essential to monitor and control its presence in the final product to ensure the safety, efficacy, and quality of Cyproterone acetate medications. The presence of this impurity can affect the overall performance and side effects profile of the drug, making it crucial to maintain strict quality control standards during the manufacturing process.

Upstream product

• 66212-25-7 1,4,6-triene-3,20-dione-17α-hydroxyprogesterone 
• 2098-65-9 17α-hydroxy-1α,2α-methylene-4,6-pregnadiene-3,20-dione 
• 2701-50-0 1,2α-methylene-Δ4,6-pregnadiene-17α-ol-3,20-dione-17-acetate 

Downstream Products

• 17183-98-1 6-chloro-1α-chloromethyl-Δ4,6-pregnadien-17α-ol-3,20-dione-17-acetate 

Relevant academic research and scientific papers

Production technology and production device of c`yproterone acetate

The invention discloses a cyproterone acetate production device. The cyproterone acetate production device comprises a reaction kettle, an elutriation kettle, a centrifugal machine, a concentration kettle, a decoloration kettle and a drying device, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder; a motor is arranged on the bottom surface of the outercylinder; exhausting fan blades, cylinder type impellers and vortex impellers are arranged on a rotating shaft of the motor; the exhausting fan blades are arranged between the drying cylinder and thebottom surface of the outer barrel; the cylinder type impellers are arranged between the drying cylinder and the inner cylinder; the vortex impellers are arranged at the bottom of the inner cylinder;an infrared ray heating pipe is arranged on the top surface of the inner cylinder; a rotating air purifying ring is arranged at the upper end of a sandwiching chamber of the outer cylinder; a mountingring is arranged on a top plate, and a gear ring is arranged in the mounting ring; screw rods and slide bars are arranged at the bottom of the mounting ring annularly and evenly in a staggering manner; pinions are arranged on the tops of the screw rods and are meshed with the gear ring; one of the screw rods is connected to an operating crank; a turnover cover is arranged on the top end of the mounting ring; and a tray is arranged on the screw rods. The cyproterone acetate production device can reduce the preparation time of intermediate products in the production process of cyproterone acetate, and realizes the rapid high-quality production of the cyproterone acetate.

Further syntheses of cyproterone acetate

The present invention relates to improved methods for synthesising cyproterone acetate (17α-Acetoxy-6-chloro-1α, 2α-methylene-4,6-pregnadiene-3,20-dione) from solasodine. The methods of the invention are shorter as those of the prior art and therefore more economic.