2701-50-0

Usage

Uses

Used in Pharmaceutical Industry:
17-Hydroxy-1a,2a-methylenepregna-4,6-diene-3,20-dione acetate is used as an impurity in the production of Cyproterone acetate for the pharmaceutical industry. Its presence is significant as it can affect the quality, efficacy, and safety of the final drug product. Therefore, monitoring and controlling the levels of this impurity are crucial in ensuring the overall quality of Cyproterone acetate.
Used in Quality Control and Regulatory Compliance:
In the pharmaceutical industry, 17-Hydroxy-1a,2a-methylenepregna-4,6-diene-3,20-dione acetate is used as a reference material for quality control and regulatory compliance purposes. It helps in the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or other chromatographic techniques, to accurately quantify and identify impurities in Cyproterone acetate products. This ensures that the drug meets the required standards and guidelines set by regulatory authorities.
Used in Research and Development:
17-Hydroxy-1a,2a-methylenepregna-4,6-diene-3,20-dione acetate is also utilized in research and development for the study of its chemical properties, structural characteristics, and potential applications. Researchers may investigate its interactions with other molecules, its effects on biological systems, and its potential use in the development of new drugs or drug delivery systems.

InChI:InChI=1/C24H30O4/c1-13(25)24(28-14(2)26)10-8-18-16-6-5-15-11-21(27)17-12-20(17)23(15,4)19(16)7-9-22(18,24)3/h5-6,11,16-20H,7-10,12H2,1-4H3/t16-,17+,18-,19-,20-,22-,23-,24-/m0/s1

Upstream product

• 2098-65-9 17α-hydroxy-1α,2α-methylene-4,6-pregnadiene-3,20-dione 
• 108-24-7 acetic anhydride 
• 66212-25-7 1,4,6-triene-3,20-dione-17α-hydroxyprogesterone 

Downstream Products

• 17183-98-1 6-chloro-1α-chloromethyl-Δ4,6-pregnadien-17α-ol-3,20-dione-17-acetate 
• 427-51-0 cyproterone acetate 
• 15423-97-9 1,2α-methylene-6,7α-oxido-Δ4-pregnen-17α-ol-3,20-dione-17-acetate 

Relevant academic research and scientific papers

Preparation process of cyproterone acetate (by machine translation)

The invention relates to a preparation process of cyproterone acetate, which comprises the following steps: ketal reaction; cyclopropanecarboxylic hydrolysis reaction; acetyl reaction; epoxy reaction; chlorinated reaction; a cyclization reaction; the invention can overcome the original process product is difficult to solve in the benzene remains the problem of, and the start is simple in raw material, reaction is stable, the total yield is high. (by machine translation)

Production technology and production device of c`yproterone acetate

The invention discloses a cyproterone acetate production device. The cyproterone acetate production device comprises a reaction kettle, an elutriation kettle, a centrifugal machine, a concentration kettle, a decoloration kettle and a drying device, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder; a motor is arranged on the bottom surface of the outercylinder; exhausting fan blades, cylinder type impellers and vortex impellers are arranged on a rotating shaft of the motor; the exhausting fan blades are arranged between the drying cylinder and thebottom surface of the outer barrel; the cylinder type impellers are arranged between the drying cylinder and the inner cylinder; the vortex impellers are arranged at the bottom of the inner cylinder;an infrared ray heating pipe is arranged on the top surface of the inner cylinder; a rotating air purifying ring is arranged at the upper end of a sandwiching chamber of the outer cylinder; a mountingring is arranged on a top plate, and a gear ring is arranged in the mounting ring; screw rods and slide bars are arranged at the bottom of the mounting ring annularly and evenly in a staggering manner; pinions are arranged on the tops of the screw rods and are meshed with the gear ring; one of the screw rods is connected to an operating crank; a turnover cover is arranged on the top end of the mounting ring; and a tray is arranged on the screw rods. The cyproterone acetate production device can reduce the preparation time of intermediate products in the production process of cyproterone acetate, and realizes the rapid high-quality production of the cyproterone acetate.