172939-50-3

Basic information

• Product Name: 8-bromo-4-methylquinoline
• Synonyms: 8-bromo-4-methylquinoline;Quinoline, 8-broMo-4-Methyl-;8-Bromo-4-methylquinolin
• CAS NO: 172939-50-3
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.084
• Mol File: 172939-50-3.mol

Chemical Properties

• Boiling Point: 315.773 °C at 760 mmHg
• Flash Point: 144.774 °C
• Appearance: /
• Density: 1.488 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-bromo-4-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromo-4-methylquinoline(172939-50-3)
• EPA Substance Registry System: 8-bromo-4-methylquinoline(172939-50-3)

Safety Data

• Hazardous Substances Data: 172939-50-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-bromo-4-methylquinoline is used as a synthetic intermediate for the development of various biologically active compounds. Its unique structure and reactivity contribute to the creation of pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 8-bromo-4-methylquinoline serves as a key intermediate in the synthesis of compounds with pesticidal or herbicidal properties, aiding in the development of effective crop protection agents.
Used in Organic Synthesis:
8-bromo-4-methylquinoline is utilized as a building block in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications across different industries. Its versatility in reactions makes it an essential component in the synthesis of complex organic molecules.

InChI:InChI=1/C10H8BrN/c1-7-5-6-12-10-8(7)3-2-4-9(10)11/h2-6H,1H3

Upstream product

• 62748-01-0 4-methyl-8-aminoquinoline 
• 78-94-4 methyl vinyl ketone 
• 615-36-1 2-bromoaniline 

Relevant articles and documents

Synthesis and antileishmanial evaluation of thiazole orange analogs

Cyanine compounds have previously shown excellent in vitro and promising in vivo antileishmanial efficacy, but the potential toxicity of these agents is a concern. A series of 22 analogs of thiazole orange ((Z)-1-methyl-4-((3-methylbenzo[d]thiazol-2(3H)-ylidene)methyl)quinolin-1-ium salt), a commercial cyanine dye with antileishmanial activity, were synthesized in an effort to increase the selectivity of such compounds while maintaining efficacy. Cyanines possessing substitutions on the quinolinium ring system displayed potency against Leishmania donovani axenic amastigotes that differed little from the parent compound (IC50 12–42 nM), while ring disjunction analogs were both less potent and less toxic. Changes in DNA melting temperature were modest when synthetic oligonucleotides were incubated with selected analogs (ΔTm ≤ 5 °C), with ring disjunction analogs showing the least effect on this parameter. Despite the high antileishmanial potency of the target compounds, their toxicity and relatively flat SAR suggests that further information regarding the target(s) of these molecules is needed to aid their development as antileishmanials.

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The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

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The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

ISOXAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS

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