62748-01-0

Basic information

• Product Name: 8-Amino-4-methylquinoline
• Synonyms: 4-methyl-8-Quinolinamine;8-Amino-4-methylquinoline;4-methylquinolin-8-amine;8-QuinolinaMine, 4-Methyl-;8-AMino-4-Methylquinolin;4-Methylquinolin-8-amine, 8-Amino-4-methyl-1-azanapthalene
• CAS NO: 62748-01-0
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• EINECS: 681-547-8
• Mol File: 62748-01-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 84 °C
• Boiling Point: 334.4 °C at 760 mmHg
• Flash Point: 182.5 °C
• Appearance: /
• Density: 1.169 g/cm³
• Vapor Pressure: 0.000128mmHg at 25°C
• Refractive Index: 1.681
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.74±0.13(Predicted)
• CAS DataBase Reference: 8-Amino-4-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Amino-4-methylquinoline(62748-01-0)
• EPA Substance Registry System: 8-Amino-4-methylquinoline(62748-01-0)

Safety Data

• Hazardous Substances Data: 62748-01-0(Hazardous Substances Data)

Usage

General Description

8-Amino-4-methylquinoline is a chemical compound with the molecular formula C10H10N2. It is a derivative of quinoline, consisting of a quinoline ring with an amino group at the 8th position and a methyl group at the 4th position. 8-Amino-4-methylquinoline is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It has been studied for its potential anti-inflammatory and antibacterial properties, as well as its use in the development of new drug molecules. 8-Amino-4-methylquinoline is also known for its fluorescence properties, making it useful in analytical chemistry and bioimaging applications. Overall, this compound has a variety of potential uses in the fields of medicine, chemistry, and material science.

InChI:InChI=1/C10H10N2/c1-7-5-6-12-10-8(7)3-2-4-9(10)11/h2-6H,11H2,1H3

Upstream product

• 98-95-3 nitrobenzene 
• 62-53-3 aniline 
• 50821-72-2 quinolone-4-carbonyl chloride 
• 2801-29-8 4-methyl-8-nitroquinoline 
• 7440-44-0 pyrographite 
• 858196-11-9 4-methyl-8-nitro-quinoline-1-oxide 
• 54965-58-1 2-chloro-4-methyl-8-nitroquinoline 
• 4053-40-1 4-methylquinoline 1-oxide 
• 634-47-9 2-chloro-4-methylquinoline 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 90-04-0 2-methoxy-phenylamine 
• 88-74-4 2-nitro-aniline 
• 3846-73-9 4-methylquinolin-8-ol 
• 855639-84-8 (4-methyl-8-nitro-[2]quinolyl)-hydrazine 

Downstream Products

• 3248-05-3 4,7-Dimethyl-1,10-phenanthroline 
• 172939-50-3 8-bromo-4-methylquinoline 
• 35817-47-1 4-methyl-8-chloroquinoline 
• 85656-75-3 2,4,6-Trimethyl-benzenesulfonate1-amino-8-formylamino-4-methyl-quinolinium; 
• 390802-35-4 ((C₁₂H₆N₂C₆H₄OCH₃)CH₂CH₂)2C₆H₄ 
• 674283-20-6 C₆H₄(C₂H₄C₁₂H₆N₂C₆H₄Br)2 
• 351184-24-2 4-methyl-7-anisyl-1,10-phenanthroline 

Relevant articles and documents

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Transition-Metal-Free Regioselective C–H Bond Fluorination of 8-Amidoquinolines with Selectfluor

A simple and efficient transition-metal-free protocol for the regioselective C–H bond fluorination of 8-aminoquinoline scaffolds with Selectfluor was developed. The reaction has a broad substrate scope and provides facile access to the corresponding C-5 f

New nonsymmetric phenanthrolines as very effective ligands in the palladium-catalyzed carbonylation of nitrobenzene

Inspired by the results of a previous mechanistic study, a series of mostly new nonsymmetric phenanthrolines were synthesized and tested as ligands in the palladium-catalyzed reductive carbonylation reaction of nitrobenzene to methyl phenylcarbamate. Very good results were obtained when the asymmetry was of an electronic nature (a donating substituent in the para position of one of the two pyridinic rings and an electron-withdrawing or no substituent on the para position of the other pyridinic ring), but steric hindrance in the ortho or meta position retarded the reaction. The TOF for the modified system is the highest ever reported for any carbonylation reaction of nitroarenes.

Octahedral Fe(II) and Ru(II) complexes based on a new bis 1,10-phenanthroline ligand that imposes a well defined axis

A bis-chelating ligand (L1), made of two 7-(p-anisyl)-1,10-phenanthroline (phen) subunits connected with a p-(CH2)2C6H4 (CH2)2 spacer through their 4 positions, has been prepared, using Skr