173026-23-8

Basic information

• Product Name: 1-(2-Bromophenyl)-1-methylethylamine
• Synonyms: 1-(2-BROMOPHENYL)-1-METHYLETHYLAMINE;1-(1-Amino-1-methylethyl)-2-bromobenzene;BenzeneMethanaMine, 2-broMo-a,a-diMethyl-;2-(2-broMophenyl)propan-2-aMine
• CAS NO: 173026-23-8
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.1
• Mol File: 173026-23-8.mol

Chemical Properties

• Boiling Point: 255 °C
• Flash Point: 108 °C
• Appearance: /
• Density: 1.342
• Vapor Pressure: 0.0164mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(2-Bromophenyl)-1-methylethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Bromophenyl)-1-methylethylamine(173026-23-8)
• EPA Substance Registry System: 1-(2-Bromophenyl)-1-methylethylamine(173026-23-8)

Safety Data

• Hazardous Substances Data: 173026-23-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Bromophenyl)-1-methylethylamine is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-Bromophenyl)-1-methylethylamine serves as an intermediate in the production of agrochemicals. Its role in this industry is crucial for the synthesis of compounds that help improve crop protection and yield.
Used in Organic Synthesis:
Due to its structural properties, 1-(2-Bromophenyl)-1-methylethylamine is also used in organic synthesis for creating a range of organic compounds. Its versatility in this field is valuable for the development of new chemical entities with potential applications in various industries.
Safety and Handling:

InChI:InChI=1/C9H12BrN/c1-9(2,11)7-5-3-4-6-8(7)10/h3-6H,11H2,1-2H3

Upstream product

• 173026-22-7 2-bromo-α,α-dimethylbenzeneacetamide 
• 57775-06-1 2-(2-bromophenyl)-2-methylpropanenitrile 
• 7073-69-0 2-(2-bromophenyl)propanol 
• 2042-37-7 o-cyanobromobenzene 
• 75-16-1 methylmagnesium bromide 
• 610-94-6 2-bromobenzoic acid methyl ester 

Downstream Products

• 245677-32-1 1-bromo-2-[1-(dimethylamino)-1-methylethyl]benzene 

Relevant articles and documents

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Copper(I)-assisted mild and convenient synthesis of new Se-N heterocycles: Access to a promising class of GPx mimics

Benzisoselenazolines 15 and benzisoselenazines 21, designed as low molecular weight mimics of glutathione peroxidases, were synthesized for the first time. Starting from amines 13 and 14, a smooth introduction of selenium in nonactivated aryl bromides using KSeCN in the presence of CuI was developed. An equimolar quantity of CuI and the presence of Et3N as a base are necessary to achieve a complete conversion of the starting material. The reaction is feasible in various solvents such as DMF, acetonitrile, and THF. The desired new Se-N heterocycles 15 and 21 were isolated under optimized conditions in yields of 82 and 68%, respectively. Experiments have been conducted with various copper(I) and copper(II) salts, a chloroamine 17, an aryl bromide 18, and an N-acylated amine 19 to show the scope and the limitations of this method. The previously unknown sulfur analogues 20 and 22 have been synthesized in moderate yields using a slightly modified procedure. Finally, a mechanistic scheme has been proposed to discuss some interesting findings, which were obtained during the optimization process of this new introduction of selenium.

Compounds having a benzisoselen-azoline and -azine structure, method for preparing same and therapeutic uses thereof

The invention concerns novel benzisoselen-azoline and -azine derivatives. These novel derivatives have the following general formula (II): STR1 where: R1 to R8 and R10 have various meanings, in particular H, alkyl, etc . .

Effect of benzylic methyl groups on kinetic basicity of amine ligand in o-boron substituted N,N-dimethylbenzylamines

Rates of the dissociation of the intramolecular B-N coordination bond in two series of phenylborane derivatives, the boronate and diethylborane complexes, with -CHMeNMe2 or -CMe2NMe2 group at the o-position were determined