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BOC-9-AMINONONANOIC ACID, also known as 9-(Boc-amino)nonanoic Acid, is an alkane chain with a terminal carboxylic acid and Boc-protected amino groups. BOC-9-AMINONONANOIC ACID is characterized by its white solid appearance and is primarily used as a PROTAC linker in the synthesis of protein degradation tools known as proteolysis-targeting chimeras (PROTACs). The terminal carboxylic acid can react with primary amine groups in the presence of activators, such as EDC or HATU, to form a stable amide bond. Additionally, the Boc group can be deprotected under mild acidic conditions, resulting in the formation of a free amine.

173435-78-4

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173435-78-4 Usage

Uses

Used in Pharmaceutical Industry:
BOC-9-AMINONONANOIC ACID is used as a PROTAC linker for the synthesis of proteolysis-targeting chimeras (PROTACs) to facilitate the development of novel therapeutic strategies. The compound's ability to form stable amide bonds with primary amine groups and its Boc-protected amino groups make it a valuable component in the creation of these protein degradation tools, which have the potential to target and degrade specific proteins involved in various diseases.
Used in Chemical Synthesis:
BOC-9-AMINONONANOIC ACID is used as a building block in chemical synthesis, particularly for the development of new compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals. The compound's unique structure and reactivity allow for the creation of diverse molecules with specific properties and functions.
Used in Research and Development:
BOC-9-AMINONONANOIC ACID is utilized as a research tool in the study of protein degradation mechanisms and the development of new protein-targeting strategies. Its role as a PROTAC linker enables researchers to explore the potential of protein degradation as a therapeutic approach for various diseases, including cancer and neurodegenerative disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 173435-78-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,4,3 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 173435-78:
(8*1)+(7*7)+(6*3)+(5*4)+(4*3)+(3*5)+(2*7)+(1*8)=144
144 % 10 = 4
So 173435-78-4 is a valid CAS Registry Number.

173435-78-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-((tert-Butoxycarbonyl)amino)nonanoic acid

1.2 Other means of identification

Product number -
Other names 9-[(2-methylpropan-2-yl)oxycarbonylamino]nonanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:173435-78-4 SDS

173435-78-4Downstream Products

173435-78-4Relevant articles and documents

HDAC DEGRADER

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Page/Page column 37; 71, (2021/07/31)

The disclosure provides compounds of formula (I). The compounds may be used to degrade the Histone Deacetylase (HDAC) family of enzymes, particularly HDAC1, 2 and 3 that exist in corepressor complexes. Accordingly, the compounds may

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

Olaleye, Tayo O.,Brannigan, James A.,Roberts, Shirley M.,Leatherbarrow, Robin J.,Wilkinson, Anthony J.,Tate, Edward W.

supporting information, p. 8132 - 8137 (2015/01/08)

N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub-micromolar peptidomimetic inhibitors of Plasmodium and Leishmania NMTs. High-resolution structures of these inhibitors with Plasmodium and Leishmania NMTs permit a comparative analysis of binding modes, and provide the first crystal structure evidence for a ternary NMT-Coenzyme A/myristoylated peptide product complex. This journal is

COVALENT INHIBITION OF BACTERIAL QUORUM SENSING

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Page/Page column 18-19, (2011/02/24)

Inhibitors of bacterial communication, such as quorum sensing, and method of use and manufacture thereof.

Covalent inhibition of bacterial quorum sensing

Amara, Neri,Mashiach, Roi,Amar, Dotan,Krief, Pnina,Spieser, Stephane A. H.,Bottomley, Matthew J.,Aharoni, Amir,Meijler, Michael M.

supporting information; experimental part, p. 10610 - 10619 (2009/12/04)

Chemical coordination of gene expression among bacteria as a function of population density is regulated by a mechanism known as 'quorum sensing' (QS). QS in Pseudomonas aeruginosa, an opportunistic pathogen that causes disease in immunocompromised patients, is mediated by binding of the transcriptional activator, LasR, to its ligand, 3-oxo-C12-HSL, leading to population-wide secretion of virulence factors and biofilm formation. We have targeted QS in P. aeruginosa with a set of electrophilic probes designed to covalently bind Cys79 in the LasR binding pocket, leading to specific inhibition of QS-regulated gene expression and concomitant reduction of virulence factor secretion and biofilm formation. This first example of covalent modification of a QS receptor provides a new tool to study molecular mechanisms of bacterial group behavior and could lead to new strategies for targeting bacterial virulence.

Cyclic imino derivatives and pharmaceutical compositions containing them

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, (2008/06/13)

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.

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