175131-93-8Relevant articles and documents
PD-1/PD-L1 inhibitor and application thereof
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Paragraph 0036-0046, (2021/02/20)
The invention relates to the field of molecular immunology, and particularly discloses a PD-1/PD-L1 inhibitor and application thereof. The PD-1/PD-L1 inhibitor comprises S-cyanomethyl-L-cysteine, activation of lymphocytes is promoted by releasing H2S, PD-1 gene expression is down-regulated, and PD-L1 gene expression of liver cancer cells is down-regulated, so that a PD-1/PD-L1 pathway is inhibited, cancer cell immune escape reaction is blocked, the immune response capacity of the lymphocytes to HepG2 cells is enhanced, the inhibition effect of the lymphocytes on the liver cancer cells is enhanced, the immune function of mice is also enhanced, and the cancer inhibition effect of quinoline derivatives of a tumor targeted drug N isostere tectoridin can also be effectively enhanced.
Efficient S-alkylation of cysteine in the presence of 1,1,3,3- tetramethylguanidine
W?ostowski, Marek,Czarnocka, Sylwia,MacIejewski, Piotr
experimental part, p. 5977 - 5979 (2010/11/21)
The synthesis of S-alkylated cysteine derivatives was carried out successfully in the presence of 1,1,3,3-tetramethylguanidine. Alkylation proceeded in high yields on unprotected amino acids and peptides containing a sulfhydryl group.
