175461-34-4

Basic information

• Product Name: (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE
• Synonyms: (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE;2,6-Dichloro-N,N-dimethylpyridin-4-amine
• CAS NO: 175461-34-4
• Molecular Formula: C₇H₈Cl₂N₂
• Molecular Weight: 191.05782
• Mol File: 175461-34-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE(175461-34-4)
• EPA Substance Registry System: (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE(175461-34-4)

Safety Data

• Hazardous Substances Data: 175461-34-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE is used as a precursor in the creation of agrochemicals, potentially enhancing crop protection and management strategies.
Used in Organic Chemistry Research:
As a building block in organic chemistry, (2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE is utilized for the exploration of new chemical reactions and the synthesis of complex organic molecules for various applications.
Used as a Tool Compound in Biological and Pharmacological Research:
(2,6-DICHLORO-PYRIDIN-4-YL)-DIMETHYL-AMINE serves as a tool compound in research, aiding scientists in understanding its biological and pharmacological activities, which could lead to the discovery of new therapeutic agents or chemical processes.

Upstream product

• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 74-88-4 methyl iodide 
• 2587-00-0 2,6-dichloropyridine N-oxide 
• 16063-69-7 2,4,6-trichloropyridine 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 
• 98027-84-0 2,6-dichloro-4-iodopyridine 
• 2402-78-0 2,6-dichloropyridine 

Relevant articles and documents

When Donors Turn into Acceptors: Ground and Excited State Properties of FeII Complexes with Amine-Substituted Tridentate Bis-imidazole-2-ylidene Pyridine Ligands

In search of new ligand motifs for photoactive iron(II) complexes with long-lived MLCT states, a series of six complexes with tridentate amine-functionalized bis-n-heterocyclic carbene (NHC)-pyridine ligands is presented. In the homoleptic complexes imidazole-, methylimidazole-, or benzimidazole-2-ylidene, NHC donors are employed in combination with pyridine, functionalized in the 4-position by dimethylamine or dibenzylamine. The effects of these different functionalities on the electronic structure of the complexes are examined through detailed ground state characterization by NMR, single crystal X-ray diffraction, as well as electrochemical and spectroscopic methods. The net influence of these different functionalities on orbital-orbital and electrostatic ligand-iron interactions is investigated thoroughly by density functional theory, and changes in the excited state behavior and lifetimes are finally examined by ultrafast optical spectroscopy. Great deviations of the initially expected effects by substitution in 4-position on the photochemical properties are observed, together with a significantly increased -acceptor interaction strength in the benzimidazole-2-ylidene functionalized complexes.

Synthesis, Characterization, and DFT Analysis of Bis-Terpyridyl-Based Molecular Cobalt Complexes

Terpyridine ligands are widely used in chemistry and material sciences owing to their ability to form stable molecular complexes with a large variety of metal ions. In that context, variations of the substituents on the terpyridine ligand allow modulation of the material properties. Applying the Stille cross-coupling reaction, we prepared with good yields a new series of terpyridine ligands possessing quinoline-type moieties in ortho, meta, and para positions and dimethylamino substituents at central or distal positions. The corresponding cobalt(II) complexes were synthesized and fully characterized by elemental analysis, single-crystal X-ray crystallography, mass spectrometry, and UV-vis, 1H NMR, and Fourier transform infrared (FT-IR) spectroscopy as well as by cyclic voltammetry (CV). Density functional theory (DFT) calculations were performed to investigate the electronic structure of all the Co(II) bis-terpyridyl molecular complexes. In this work, we show that terpyridine ligand functionalization allows tuning the redox potentials of the Co(III)/Co(II), Co(II)/Co(I), and Co(I)/Co(I) (tpy)?- couples over a 1 V range.

Stereo- and Regioselective Alkyne Hydrometallation with Gold(III) Hydrides

The hydroauration of internal and terminal alkynes by gold(III) hydride complexes [(C^N^C)AuH] was found to be mediated by radicals and proceeds by an unexpected binuclear outer-sphere mechanism to cleanly form trans-insertion products. Radical precursors such as azobisisobutyronitrile lead to a drastic rate enhancement. DFT calculations support the proposed radical mechanism, with very low activation barriers, and rule out mononuclear mechanistic alternatives. These alkyne hydroaurations are highly regio- and stereospecific for the formation of Z-vinyl isomers, with Z/E ratios of >99:1 in most cases.

Ligand-promoted ortho-C-H amination with Pd catalysts

2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable PdII-catalyzed Csp2-H activation reactions directed by weakly coordinating functional groups.

COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS

Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick

(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.