Fused tricyclic β-lactams via intramolecular aryl radical cyclization
Easy access to fused tricyclic β-lactams starting with o-bromobenzaldehyde and allyl amine has been devised using intramolecular aryl radical cyclization under the influence of tributyltin hydride. The major product resulted from exo cyclization leading to the formation of a 6-membered ring and thus a tricyclic β-lactam. In some cases, a minor product was a 7-membered ring-containing tricyclic β-lactam formed by endo cyclization.
Banik, Bimal K.,Subbaraju, Gottumukkala V.,Manhas, Maghar S.,Bose, Ajay K.
Tetracyclic isoquinolones and quinazolones via aryl radical cyclizations
The Schiff base from o-bromobenzaldehyde and allylamine was allowed to react with homophthalic anhydride to form an isoquinolone. Reaction of the same Schiff base with isatoic anhydride led to a quinazolone. Generation of a free radical from the bromoaryl
Banik, Bimal K.,Raju, Vegesna S.,Manhas, Maghar S.,Bose, Ajay K.
p. 639 - 642
(2007/10/03)
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