176175-97-6

Basic information

• Product Name: 1-(benzyloxy)-3,5-difluorobenzene
• Synonyms: 1-(benzyloxy)-3,5-difluorobenzene;1,3-difluoro-5-(phenylmethoxy)benzene
• CAS NO: 176175-97-6
• Molecular Formula: C₁₃H₁₀F₂O
• Molecular Weight: 220.2147064
• Mol File: 176175-97-6.mol

Chemical Properties

• Boiling Point: 266.001 °C at 760 mmHg
• Flash Point: 121.942 °C
• Appearance: /
• Density: 1.206 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(benzyloxy)-3,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-3,5-difluorobenzene(176175-97-6)
• EPA Substance Registry System: 1-(benzyloxy)-3,5-difluorobenzene(176175-97-6)

Safety Data

• Hazardous Substances Data: 176175-97-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(Benzyloxy)-3,5-difluorobenzene is used as a building block in organic synthesis for the creation of various biologically active compounds. Its unique structure allows for the development of new molecules with potential applications in different fields.
Used in Pharmaceutical Research:
In pharmaceutical research, 1-(Benzyloxy)-3,5-difluorobenzene is utilized as a starting material for the synthesis of compounds with therapeutic potential. The presence of fluorine atoms can enhance the pharmacokinetic and pharmacodynamic properties of the resulting molecules, leading to improved drug candidates.
Used in Agrochemical Production:
1-(Benzyloxy)-3,5-difluorobenzene is employed as a starting material in the production of agrochemicals. Its unique structure can contribute to the development of effective and environmentally friendly pesticides or herbicides.
Used in Fine Chemicals Industry:
In the fine chemicals industry, 1-(Benzyloxy)-3,5-difluorobenzene is used as a key intermediate for the synthesis of specialty chemicals. Its versatility and unique properties make it suitable for the production of high-value compounds used in various applications, such as fragrances, dyes, or advanced materials.

Upstream product

• 2713-34-0 3,5-difluorophenol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 372-38-3 1,3,5-trifluorobenzene 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

Regioselective approach to multisubstituted benzenes

Various multisubstituted benzenes were synthesized in highly chemo- and regioselective manners via nucleophilic aromatic substitution and ortho-metalation from 1,3,5-trifluorobenzene.

Total Syntheses of Perenniporides

The total syntheses of perenniporide A (1) and related compounds have been achieved. Starting from 1,3,5-trifluorobenzene (9), difluorodienone 6 was obtained by oxidative dearomatization, which served as a platform for the high-pressure cycloaddition and for the introduction of the C3-methoxy group. The synthesis allowed access to the natural congeners 2 and 3, enabling assignment of the absolute structures of these natural products.

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.

NOVEL INHIBITORS

The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein R1, R2, R3, R4 and R5 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N- terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.

A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines

Two independent synthetic pathways for the preparation of 4-methoxy, 4-benzyloxy and 4-hydroxy-2,6-difluoroanilines, versatile building blocks in medicinal chemistry, based on diazonium coupling or Curtius-type rearrangements are presented.