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Methyl 2-ethoxyacetate is an organic compound that possesses unique chemical properties, making it a versatile substance in various applications across different industries. It is characterized by its ester functional group, which contributes to its reactivity and utility in chemical reactions.

17640-26-5

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17640-26-5 Usage

Uses

1. Used in Pharmaceutical Industry:
Methyl 2-ethoxyacetate is used as an intermediate in the synthesis of various pharmaceutical compounds due to its ability to participate in hydrogenation reactions facilitated by chiral spiro iridium/phosphino-oxazoline complexes. This makes it a valuable component in the development of new drugs and medications.
2. Used in Agricultural Industry:
Methyl 2-ethoxyacetate is used as an antifungal agent to help protect crops from fungal infections. Its partial antifungal properties contribute to maintaining the health and quality of agricultural products, reducing the need for other potentially harmful chemical treatments.
3. Used in Chemical Synthesis:
In the field of chemical synthesis, methyl 2-ethoxyacetate serves as a key building block for the creation of more complex molecules. Its reactivity and compatibility with various reagents make it a preferred choice for researchers and chemists working on the development of new compounds with specific applications.
4. Used in Research and Development:
Methyl 2-ethoxyacetate is utilized in research and development settings to study its properties and potential applications. Its unique characteristics make it an interesting subject for scientific inquiry, with the potential to lead to new discoveries and innovations in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 17640-26-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,4 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 17640-26:
(7*1)+(6*7)+(5*6)+(4*4)+(3*0)+(2*2)+(1*6)=105
105 % 10 = 5
So 17640-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H10O3/c1-3-8-4-5(6)7-2/h3-4H2,1-2H3

17640-26-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-ethoxyacetate

1.2 Other means of identification

Product number -
Other names Ethoxyessigsaeure-methylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17640-26-5 SDS

17640-26-5Relevant articles and documents

Larvicidal activity and click synthesis of 2-alkoxyl-2-(1,2,3-triazole-1- yl)acetamide library

Su, Na-Na,Xiong, Li-Xia,Yu, Shu-Jing,Zhang, Xiao,Cui, Can,Li, Zheng-Ming,Zhao, Wei-Guang

, p. 484 - 493 (2013/07/28)

Heterogeneous copper-in-charcoal-catalyzed click synthesis in 96-well polypropylene filter plates is an efficient method for the rapid generation of sufficient pure 2-alkoxyl-2-(1,2,3-triazole-1-yl) acetamide derivatives library by simple filtration, which directly assay the products for larvicidal activity against mosquitoes. In this procedure, copper nanoparticles on charcoal were arrayed into each well on a 96-well plate, reagents were delivered using a pipette gun, and a constant temperature shaker bath was used to complete the click reaction in 24-72 hours under temperature-controlled conditions. The results of bioassays indicated that the target compounds possessed excellent larvacidal activities against mosquitoes. In particular, the larvacidal activities against mosquitoes of compounds 8[2,3] and 8[7,1] at 2g.mL-1 were 100% and 73%, respectively.

Reaction of methyl diazoacetate with aldehydes, amines, thiols, alcohols and acids over transition metal-exchanged clays

Phukan, Prodeep,Mohan, Jakkam Madan,Sudalai, Arumugam

, p. 3685 - 3689 (2007/10/03)

Metal-exchanged clays (M = Rh and Cu) catalyze effectively the reaction of methyl diazoacetate with various aldehydes, affording the corresponding β-keto esters in high yields. They have also been effective in the decomposition of methyl diazoacetate to form metallocarbenes which, in turn, successfully insert into X-H (X = N, O, S, CO2) bonds of a variety of amines, aldehydes, thiols and acids, thereby producing the corresponding esters. The Royal Society of Chemistry 1999.

Reactions of Carbenes with Oxetane and with Oxetane/ Methanol Mixtures

Kirmse, Wolfgang,Lelgemann, Rudolf,Friedrich, Klaus

, p. 1853 - 1863 (2007/10/02)

Ethoxycarbonylcarbene, bis(methoxycarbonyl)carbene, phenylcarbene (17a), diphenylcarbene (17b), fluorenylidene (17c), 2-furylcarbene (31a), 2-furyl(phenyl)carbene (31b), 4-oxo-2,5-cyclohexadienylidene (40), and 4,4-dimethyl-2,5-cyclohexadienylidene (53) were generated by photolysis of the appropriate diazo compounds.With neat oxetane, most of these carbenes react by competitive C-H insertion (B -> A, Scheme 1) and ylide formation (B -> C). 31a and 40 do not insert into C-H bonds; 31b does not attack oxetane but rearranges exclusively with formation of 26.The ylides undergo Stevens rearrangement to give tetrahydrofurans (C -> D) and α',β-elimination, leading to allyl ethers (C -> E).With oxetane/ methanol mixtures, the intervention of oxonium ions (H) is indicated by the formation of 1,3-dialkoxypropanes (I).The oxonium ions arise either by protonation of the ylides (C -> H) or by protonation of the carbenes (B -> G), followed by electrophilic attack of the carbocations (G) at oxetane (G -> H).The former route is followed by the alkoxycarbonylcarbenes and by 40; the ylides derived from the remaining carbenes do not react with methanol, owing to their rapid Stevens rearrangements.Protonation of the carbenes 17b, 31, and 53 is clearly indicated by their product ratios and, for 31, by the formation of isomeric ethers (33, 36).The more electrophilic carbenes discriminate but slightly between oxetane and methanol while the more nucleophilic carbenes (17b, 31, 53) prefer the protic methanol strongly over the aprotic oxetane. Key Words: Carbenes/ Oxygen ylides/ Stevens rearrangement/ Oxonium ions/ Insertion, O-H/ Ylides

OXYGEN YLIDES-I. REACTIONS OF CARBENES WITH OXETANE

Friedrich, Klaus,Jansen, Ulrich,Kirmse, Wolfgang

, p. 193 - 196 (2007/10/02)

The ylides generated from carbenes (:CH2, :CHCO2Et, :CHPh) and oxetane in the presence of methanol undergo Stevens rearrangement and protonation competitively, yielding tetrahydrofurans and 1,3-dialkoxycyclopropanes as major products.

163. Reactions of Alkenediazonium Salts. Part 1. 2,2-Diethoxyethenediazonium Hexachloroantimonate: A Diazonium, a Carbenium or an Oxonium Salt?

Szele, Ivanka,Tencer, Michal,Zollinger, Heinrich

, p. 1691 - 1703 (2007/10/02)

Reactions of the title compound 1 with various nucleophiles have been studied.The salt behaves like an alkylating agent towards ethers, alcohols and water forming ethyl diazoacetate (2), which reacts further with excess of the nucleophile.A solvent cage mechanism accounting for the observed products is proposed.Thermal decomposition in inert solvents leads to the alkylation of the counter-ion, i.e. formation of chloroethane, and in anisole, alkylation and chlorination of the solvent are also observed.With a standard coupling component, 2-naphtholate ion, no azo coupling reaction of 1 is observed, but instead 14-methyl-14H-dibenzoxanthene (17) is formed.The products of the reaction with diethylamine are diethylcyanoformamide (18) and ethyl diethylcarbamate (19).None of the chemistry of salt 1 is explained by the intervention of vinyl cations expected to be formed in a heterolytic dediazoniation.The predominant pathways seems to involve reactions of an oxonium salt (alkylating properties) or, in the case of diethylamine, a carbenium salt (primary nucleophilic attack on the β-C-atom of 1).The free energy barrier to C=C rotation in 1 is estimated to be 75 to 77 kJ/mol (18.0 to 18.5 kcal/mol), a value which falls between those expected for a double and a single bond.

The Reactivity of Carbenes from Photolysis of Diazo-Compounds towards Carbon-Hydrogen Bonds. Effects of Structure, Temperature, and Matrix on the Insertion Selectivity

Tomioka, Hideo,Itoh, Masami,Yamakawa, Shyoji,Izawa, Yasuji

, p. 603 - 609 (2007/10/02)

Direct and/or sensitized photolyses of diazo-acetate (1a) and -malonate (1b) in hydrocarbons and ether were investigated at various temperatures in order to learn more about the nature of the C-H insertion process and the structural factors governing positional selectivity within the matrix.Photolysis of the diazo-compounds in a rigid matrix resulted in a marked decrease in the insertion selectivity, which may be interpreted as indicating that the matrix imposes severe steric demand especially on the direct C-H insertion process of the singlet carbene.The addition of a sensitizer in matrix photolysis causes a marked increase in the selectivity in the case of (1a), as is observed in the comparable liquid-phase experiment, but it causes a decrease in the case of (1b).This is interpreted as suggesting that the excited triplet (1b) itself is involved in C-H insertion under these conditions.More extensive temperature studies show that, as the temperature decreases, the C-H insertion selectivity of :CHCO2R decreases regularly regardless of the reaction phase, whereas that of :C(CO2R)2 increases in the liquid phase but decreases in the solid phase.This difference in the temperature dependence is explained by assuming that the singlet carbene is responsible for the C-H insertion of :CHCO2R throughout the temperature range studied, while both singlet and triplet are involved in the insertion of :C(CO2R)2.

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