- Gold(I)-catalyzed cycloisomerization of enynes containing cyclopropenes
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Goldenyne: Gold-catalyzed cycloisomerization reactions of propargyl cyclopropenes afford benzene derivatives in a highly efficient manner. The reaction either proceeds through a mechanism with or without double and triple bond cleavage, depending on the substituents (see scheme). Copyright
- Li, Changkun,Zeng, Yi,Zhang, Hang,Feng, Jiajie,Zhang, Yan,Wang, Jianbo
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supporting information; experimental part
p. 6413 - 6417
(2010/11/19)
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- Rh(I)-catalyzed carbonylative carbocyclization of tethered ene- and yne-cyclopropenes
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Rh(I)-catalyzed carbonylative carbocyclization of ene- and yne-cyclopropene systems provides cyclohexenones and phenols with high efficiency, respectively.
- Li, Changkun,Zhang, Hang,Feng, Jiajie,Zhang, Yan,Wang, Jianbo
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supporting information; experimental part
p. 3082 - 3085
(2010/08/20)
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- Diphenyl-cyclopropenes as selective K-agonists
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The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke. The compounds are
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- Trapping of Cyclopropenyl Radicals by 5,5-Dimethyl-1-pyrroline-N-oxide
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The possible generation of cyclopropenyl radicals by ultraviolet irradiation of different cyclopropenyl derivatives in fluid solution and in the presence of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as spin trap has been detected by electron paramagnetic re
- Cano, Montserrat,Quintana, Jordi,Julia, Luis,Camps, Francisco,Joglar, Jesus
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p. 5096 - 5099
(2007/10/03)
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- DIPHENYL-CYCLOPROPENES AS SELECTIVE K-AGONISTS
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Diphenyl-cyclopropene derivatives, their nontoxic, pharmaceutically acceptable acid addition salts and compositions are kapa opiods useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irri
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- Trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists
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The synthesis and kappa opioid agonist activities of some lipophilic analogues of the kappa opioid agonist U-50488 incorporating motifs bearing two aromatic rings in place of the 3,4-dichlorophenyl group are described. Trans 2,3-diphenyl-N-methyl-N[2-(1-pyrrolidinyl)cyclohexyl]-2-cyclopropene-1 -carboxamide, 7, is a potent kappa opioid agonist. A diphenylcyclopropene analogue of CI-977, trans 2,3-diphenyl-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-2 -cyclopropene-1-carboxamide, 13, is a highly lipophilic chemically novel potent selective kappa opioid agonist.
- Sabin,Horwell,McKnight,Broqua
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p. 291 - 296
(2007/10/03)
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- The Attempted Generation of a Methylene-Bridged Trimethylenemethane Biradical (1,3-Diphenyl-2-methylenecyclobutane-1,3-diyl) by Oxidation of endo-1,3-Diphenyl-2-(phenylselenomethyl)bicyclobutane.
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Copper-catalysed addition of ethyl diazoacetate to diphenylacetylene and hydrolysis gives 1,2-diphenylcyclopropane-3-carboxylic acid (18b).Conversion to the acid chloride (18c) and reduction with lithium aluminium tri-tert-butoxy hydride gives 1,2-dipheny
- Bushby, Richard J.,Jesudason, Malini V.
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p. 1144 - 1170
(2007/10/02)
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