- Reconfiguration of π-conjugated superstructures enabled by redox-assisted assembly
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We show that n-doping supramolecular assemblies built from perylene diimide units provides a means to modulate the structure-function properties of these materials. In addition to highlighting the design principles, a combination of spectroscopic and micr
- Liu, Kaixuan,Mukhopadhyay, Arindam,Ashcraft, Adam,Liu, Chuan,Levy, Adam,Blackwelder, Patricia,Olivier, Jean-Hubert
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- Synthesis and biological evaluation of Matijing-Su derivatives as potent anti-HBV agents
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A series of Matijing-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l- phenylalanol) derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity in 2.2.15 cells. The IC50 of compounds 14a (0.71 μM), 13c (2.85 μM), 13b (4.37 μM), etc. and the selective index of 13g (161.01), 13c (90.45), 13a (85.09) etc. of the inhibition on the replication of HBV DNA were better than those of the positive control lamivudine (IC50: 82.42 μM, SI: 41.59). Compounds 13o, 13p, and 16a also exhibited significant anti-HBV activity.
- Qiu, Jingying,Xu, Bixue,Huang, Zhengming,Pan, Weidong,Cao, Peixue,Liu, Changxiao,Hao, Xiaojiang,Song, Baoan,Liang, Guangyi
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experimental part
p. 5352 - 5360
(2011/10/12)
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