Synthesis and in vitro cytotoxicity of cryptophycins and related analogs
Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.
De Muys, Jean-Marc,Rej, Rabindra,Nguyen, Dieu,Go, Brian,Fortin, Samuel,Lavallee, Jean-Francois