179120-51-5

Basic information

• Product Name: ALTINICLINE
• Synonyms: 3-ethynyl-5-(1-methyl-2-pyrrolidinyl)pyridine;Pyridine, 3-ethynyl-5-(1-methyl-2-pyrrolidinyl)-
• CAS NO: 179120-51-5
• Molecular Formula: C12H14N2
• Molecular Weight: 186.257
• Mol File: 179120-51-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ALTINICLINE(CAS DataBase Reference)
• NIST Chemistry Reference: ALTINICLINE(179120-51-5)
• EPA Substance Registry System: ALTINICLINE(179120-51-5)

Safety Data

• Hazardous Substances Data: 179120-51-5(Hazardous Substances Data)

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 64319-85-3 3-bromo-5-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine 
• 71719-09-0 5-bromo-3-(1-methyl-2-pyrrolidinyl)pyridine 
• 71719-06-7 5-Bromo-3-(2-pyrrolidinyl)pyridine 
• 201292-62-8 3-(5-Bromo-pyridine-3-carbonyl)-1-vinyl-pyrrolidin-2-one 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 179120-73-1 5-(2-hydroxy-2-methylbut-3-ynyl)-3-(1-methyl-2-pyrrolidinyl)pyridine 

Relevant articles and documents

A Practical and Efficient Synthesis of the Selective Neuronal Acetylcholine-Gated Ion Channel Agonist (S)-(-)-5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine Maleate (SIB-1508Y)

An efficient, high-yielding synthetic procedure for the preparation of the novel neuronal acetylcholinegated ion channel agonist (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate [(S)-2, SIB-1508Y] is described. The key steps in the process include the lithium bis(trimethylsilyl)amide-mediated acylation of N-vinylpyrrolidinone with ethyl 5-bromonicotinate, a high-yielding sodium borohydride reduction of imine 5, and a new heteroaryl-alkyne cross-coupling protocol for the introduction of the ethyne moiety in (S)-2. The preparation of enantiomerically pure (S)-2 was accomplished via a combination of enantioselective reduction of imine 5 and crystallization of enantiomerically enriched 5-bromo-3-(1-methyl-2-pyrrolidinyl)pyridine (7) as the dibenzoyl-L-tartaric acid salt.

MODULATORS OF ACETYLCHOLINE RECEPTORS

The present invention provides a class of pyridine compounds which are modulators of acetylcholine receptors, i.e., compounds which displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists

MODULATORS OF ACETYLCHOLINE RECEPTORS

The present invention provides a class of pyridine compounds which are modulators of acetylcholine receptors, i.e., compounds which displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists

Modulators of acetylcholine receptors

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds

MODULATORS OF ACETYLCHOLINE RECEPTORS

gIn accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compound

METHODS FOR THE PREPARATION OF MODULATORS OF ACETYLCHOLINE RECEPTORS

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds