71719-09-0

Basic information

• Product Name: 3-BroMo-5-(1-Methylpyrrolidin-2-yl)pyridine
• Synonyms: 3-BroMo-5-(1-Methylpyrrolidin-2-yl)pyridine;Pyridine, 3-bromo-5-(1-methyl-2-pyrrolidinyl)-
• CAS NO: 71719-09-0
• Molecular Formula: C₁₀H₁₃BrN₂
• Molecular Weight: 241.12762
• Mol File: 71719-09-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-BroMo-5-(1-Methylpyrrolidin-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-5-(1-Methylpyrrolidin-2-yl)pyridine(71719-09-0)
• EPA Substance Registry System: 3-BroMo-5-(1-Methylpyrrolidin-2-yl)pyridine(71719-09-0)

Safety Data

• Hazardous Substances Data: 71719-09-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 71719-06-7 5-Bromo-3-(2-pyrrolidinyl)pyridine 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 201292-62-8 3-(5-Bromo-pyridine-3-carbonyl)-1-vinyl-pyrrolidin-2-one 
• 64319-85-3 3-bromo-5-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine 
• 1253523-01-1 methyl 2-(5-bromopyridin-3-yl)pyrrolidine-1-carboxylate 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 

Downstream Products

• 179120-51-5 SIB-1765F 
• 250682-94-1 methyl 4-[(5-(1-methyl-2-pyrrolidinyl)-3-pyridinyl)ethynyl]benzoate 

Relevant articles and documents

One-pot formation of piperidine- and pyrrolidine-substituted pyridinium salts via addition of 5-alkylaminopenta-2,4-dienals to N-acyliminium ions: Application to the synthesis of (±)-nicotine and analogs

Addition of 5-alkylaminopenta-2,4-dienals onto N-acyliminium ions, generated in situ from α-hydroxycarbamates derived from pyrrolidine or piperidine, in the presence of zinc triflate, followed by dehydrative cyclization, allowed the formation of pyridinium salts substituted at their 3-position by a five- or six-membered nitrogen heterocycle. Subsequent N-dealkylation of the pyridinium moiety and deprotection of the secondary amine or reduction of the carbamate function led to (±)-nicotine and analogs.

COMPOUNDS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF AMYLOID ASSOCIATED DISEASES

The invention is in general directed to compounds, such as tannic acid, nicotine, nicotine derivatives and pyrrolidine derivatives of nicotine, and methods for diagnosing, preventing or alleviating the symptoms of amyloid-associated diseases, for example, neuronal diseases, such as, for example, Alzheimer's disease, compounds and methods for inhibiting ion channel activity of beta amyloid, and methods of diagnostic imaging of A/3 fibrils.

MODULATORS OF ACETYLCHOLINE RECEPTORS

The present invention provides a class of pyridine compounds which are modulators of acetylcholine receptors, i.e., compounds which displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists

MODULATORS OF ACETYLCHOLINE RECEPTORS

The present invention provides a class of pyridine compounds which are modulators of acetylcholine receptors, i.e., compounds which displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists

A Practical and Efficient Synthesis of the Selective Neuronal Acetylcholine-Gated Ion Channel Agonist (S)-(-)-5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine Maleate (SIB-1508Y)

An efficient, high-yielding synthetic procedure for the preparation of the novel neuronal acetylcholinegated ion channel agonist (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate [(S)-2, SIB-1508Y] is described. The key steps in the process include the lithium bis(trimethylsilyl)amide-mediated acylation of N-vinylpyrrolidinone with ethyl 5-bromonicotinate, a high-yielding sodium borohydride reduction of imine 5, and a new heteroaryl-alkyne cross-coupling protocol for the introduction of the ethyne moiety in (S)-2. The preparation of enantiomerically pure (S)-2 was accomplished via a combination of enantioselective reduction of imine 5 and crystallization of enantiomerically enriched 5-bromo-3-(1-methyl-2-pyrrolidinyl)pyridine (7) as the dibenzoyl-L-tartaric acid salt.

MODULATORS OF ACETYLCHOLINE RECEPTORS

gIn accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compound

METHODS FOR THE PREPARATION OF MODULATORS OF ACETYLCHOLINE RECEPTORS

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds

Modulators of acetylcholine receptors

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds