179334-18-0Relevant articles and documents
First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson’s Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate
Sun, Huikai,Monenschein, Holger,Schiffer, Hans H.,Reichard, Holly A.,Kikuchi, Shota,Hopkins, Maria,Macklin, Todd K.,Hitchcock, Stephen,Adams, Mark,Green, Jason,Brown, Jason,Murphy, Sean T.,Kaushal, Nidhi,Collia, Deanna R.,Moore, Steve,Ray, William J.,English, Nicole Marion,Carlton, Mark Beresford Lewis,Brice, Nicola L.
, p. 9875 - 9890 (2021/05/06)
Parkinson’s disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor (GPCR) with highly restricted expression in dopami
INHIBITORS OF STEAROYL-COA DESATURASE
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, (2009/06/27)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
Certain substituted 1-aryl-3-piperazin-1′-yl propanones
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, (2008/06/13)
Disclosed are compounds of formula I: wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1and Ar2independently represent aryl groups; and Y is hydrogen; o
Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
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, (2008/06/13)
Disclosed are compounds of formula I: STR1 or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 i
Substituted 1-aryl-3-piperazin-1'-yl propanones
-
, (2008/06/13)
Disclosed are compounds of formula I: STR1 wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydr