- An efficient bakers' yeast catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-ones
-
Bakers' yeast (Saccharomyces cerevisiae) efficiently catalyzes the three-component Biginelli reaction of aldehydes, β-keto esters, and urea/thiourea to form 3,4-dihydropyrimidin-2-(1H)-ones in good to excellent yields.
- Kumar, Atul,Maurya, Ram Awatar
-
-
Read Online
- Borax: An ecofriendly and efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidine-2(1h)-ones under solvent-free conditions
-
Borax in the presence of a very small amount of 5M sulfuric acid efficiently catalyses the three-component condensation of an aldehyde, -ketoester, and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or 3,4-dihydropyrimidin-2(
- Nath, Jayashree,Chaudhuri, Mihir K.
-
-
Read Online
- Hydrotalcite: A novel and reusable solid catalyst for one-pot synthesis of 3,4-dihydropyrimidinones and mechanistic study under solvent free conditions
-
Synthesis of 3,4-dihydropyrimidinones/thiones, a multicomponent synthesis using ethyl acetoacetate, substituted aromatic aldehydes, and urea/thiourea has been carried out in presence of Mg-Al-CO3 and Ca-Al-CO3 hydrotalcite as a reusa
- Lal, Jaggi,Sharma, Monika,Gupta, Savita,Parashar, Priyanka,Sahu, Pramod,Agarwal
-
-
Read Online
- A Br?nsted acidic ionic liquid anchored to magnetite nanoparticles as a novel recoverable heterogeneous catalyst for the Biginelli reaction
-
In this study, simple and effective methods were used for the preparation of an ionic liquid that immobilized magnetite nanoparticles. Fe3O4nanoparticles were preparedviaa chemical co-precipitation method. Then, a SiO2shel
- Oboudatian, Hourieh Sadat,Naeimi, Hossein,Moradian, Mohsen
-
-
Read Online
- Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction
-
An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.
- Donyapeyma, Ghazaleh,Rahmatpour, Ali
-
-
- RETRACTED ARTICLE: Boric acid in magnetized water: Clean and powerful media for synthesis of 3,4-dihydropyrimidin-2(1: H)-ones
-
Water was magnetized via an external magnetic field and employed, for the first time, as a solvent in green preparation of 3,4-dihydropyrimidin-2(1H)-ones by the one-pot three-component condensation reaction using boric acid as a catalyst. Shorter reactio
- Khakyzadeh, Vahid,Moosavi-Zare, Ahmad Reza,Sheikhaleslami, Sahra,Ehsani, Amir,Sediqi, Salbin,Rezaei-Gohar, Mohammad,Jalilian, Zahra
-
p. 22751 - 22755
(2021/07/21)
-
- Efficient biocatalytic strategy for one-pot Biginelli reaction via enhanced specific effects of microwave in a circulating reactor
-
A one-pot efficient biocatalytic strategy for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones was developed in a circulating microwave reactor selecting α-chymotrypsin as the promiscuous biocatalyst. In the circulating reaction system, the combination o
- Xie, Zong-Bo,Fu, Lei-Han,Meng, Jia,Lan, Jin,Hu, Zhi-Yu,Le, Zhang-Gao
-
-
- One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones, thiones and 2-selenoxo DHPMs using 1-butyl-3-methylimidazolium hydrogen sulfate as non-halogenated ionic liquid
-
1-Butyl-3-methylimidazolium hydrogen sulfate ([BMIM][HSO4]) as a non-halogenated ionic liquid (IL) was used for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones or 2-selenoxo DHPMs in a Biginelli type multi-component reaction. By us
- Mohammadi, Behzad,Behbahani, Farahnaz K.,Marandi, Gholam B.,Mirza, Behrouz
-
-
- Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions
-
An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq
- Li, Ningbo,Wang, Yijun,Liu, Feijun,Zhao, Xin,Xu, Xinhua,An, Quan,Yun, Keming
-
-
- Synthesis, cytotoxic assessment, and molecular docking studies of 2,6-diaryl-substituted pyridine and 3,4-dihydropyrimidine-2(1H)-one scaffolds
-
Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytot
- Aghahosseini, Hamideh,Hosseinzadeh, Zahra,Ramazani, Ali,Razzaghi-Asl, Nima
-
p. 194 - 213
(2020/03/24)
-
- BiCl3-modified perlite as an effective catalyst for selective organic transformations: a green protocol
-
A new perlite supported Bismuth Chloride (BiCl3) was used as an efficient heterogeneous catalyst for the synthesis of heterocyclic compounds viz., quinoxalines and dihydropyrimidinones. Fourier-transform infrared spectroscopy (FT–IR), scanning
- Brindha, Kannan,Amutha, Parasuraman,Krishnakumar, Balu,do Nascimento Sobral, Abílio José Fraga
-
p. 4367 - 4381
(2019/05/15)
-
- Zirconium (IV) porphyrin graphene oxide: a new and efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones
-
A covalently cross-linked graphene oxide (GO) as a catalyst was prepared by a cross-linking process using the nucleophilic reaction of zirconium (IV)-coordinated 5,10,15,20-tetrakis (aminophenyl)porphyrin (ZrPPh) with carboxyl groups of the edges of GO (GO-ZrPPh). The chemical structure of catalyst was characterized by different analyses such as FT-IR, SEM, TEM, EDS, ICP, TGA and UV. All analyses confirm the occurrence of successfully covalent immobilization of ZrPPh on the GO. Also, TEM and SEM images show that ZrPPh has been immobilized in the both of the edges and the basal plane of GO. The activity of the catalyst was studied for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones via Biginelli reaction. The cross-linked catalyst is able to catalyze the reaction in short reaction times and good to excellent yields.
- Ghadamyari, Zohreh,Shiri, Ali,Khojastehnezhad, Amir,Seyedi, Seyed Mohammad
-
-
- Preparation method and application of novel ionic salicylaldehyde Schiff base zirconium complex (by machine translation)
-
The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic salicylaldehyde Schiff base zirconium complex. The cationic part is formed by coordination of zi
- -
-
Paragraph 0052-0053
(2019/11/20)
-
- Copper-doped mesoporous silica supported dual acidic ionic liquid as an efficient and cooperative reusability catalyst for Biginelli reaction
-
A series of MCM-41 supported functionalized ionic liquids doped with copper species were prepared, characterized and evaluated as catalysts in the Biginelli reaction. Most of these supported ionic liquids perform well in the reaction, especially the multifunctional copper coordinated MCM-41 supported heterogeneous catalysts (0.5)IL-TiCl5@MCM-41@Cu(15) and (0.5)IL-HSO4@MCM-41@Cu(15). The catalytic tests revealed that (0.5)IL-HSO4@MCM-41@Cu(15) was the best and powerful catalyst in the Biginelli reaction for the preparation of 3,4-dihydropyrimidinones with high to excellent yields. The catalyst can be easily separated from the reaction mixture by filtration and reused in six consecutive cycles without significant loss in catalytic activity.
- Yao, Nan,Lu, Ming,Liu, Xiao Bing,Tan, Jin,Hu, Yu Lin
-
p. 328 - 335
(2018/05/07)
-
- Bis(p-sulfoanilino)triazine-functionalized silica-coated magnetite nanoparticles as an efficient and magnetically reusable nano-catalyst for Biginelli-type reaction
-
Abstract: The preparation of bis(p-sulfoanilino)triazine-functionalized silica-coated magnetite nanoparticles and their use as a novel magnetically separable nanocatalyst for the synthesis of various Biginelli adducts are presented. The materials were characterized by various microscopic and spectroscopic techniques such as scanning electron microscopy, vibrating sample magnetometer, X-ray powder diffraction, and FT-IR spectroscopy, etc. A series of 3,4-dihydropyrimidinones or thione products were conveniently prepared by this green protocol from the reactions of aromatic aldehydes with the 1,3-dicarbonyl compounds and urea or thiourea using the catalyst under solvent-free conditions. The present method is operationally simple and offers several advantages such as good to excellent yields, short reaction times, the absence of a solvent, and simple work-up. Moreover, the aforementioned nanocatalyst can be easily recovered from the reaction mixture with the assistance of an external magnetic field and reused several times without any loss of its catalytic activity.
- Moghanian, Hassan,Fard, Mohammad Ali Bodaghi,Mobinikhaledi, Akbar,Ahadi, Najmieh
-
p. 4083 - 4101
(2018/06/19)
-
- Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine, a green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free co
-
Caffeine was found to be a natural and green and biodegradable catalyst for the one-pot, three-component condensation Biginelli reaction of β-keto esters, aromatic aldehydes and urea/thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones/thi
- Mohamadpour, Farzaneh,Lashkari, Mojtaba
-
p. 673 - 684
(2018/07/15)
-
- 2-oxo-1,2,3,4-tetrahydropyrimidines ethyl esters as potent β-glucuronidase inhibitors: One-pot synthesis, in vitro and in silico studies
-
Background: Glucuronidation is essential for the metabolism and excretion of toxic substances. β-Glucuronidase enzyme slows down the process of glucuronidation, and thus plays an important role in the on-set of colorectal carcinoma, and many other disease
- Iqbal, Sarosh,Shaikh, Nimra N.,Khan, Khalid M.,Naz, Sehrish,Ul-Haq, Zaheer,Perveen, Shahnaz,Choudhary, Muhammad I.
-
p. 818 - 830
(2018/11/30)
-
- BiVO4-NPs: an efficient nano-catalyst for the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives
-
BiVO4-NPs can be used as an efficient and reusable nano-catalyst for the promotion of the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives. The structures of the products were characteriz
- Shirini, Farhad,Lati, Monireh Pourghasemi
-
-
- Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones
-
A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR,1H NMR,13C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and R
- Kumarasamy, Dhanabal,Roy, Biswajit Gopal,Rocha-Pereira, Joana,Neyts, Johan,Nanjappan, Satheeshkumar,Maity, Subhasis,Mookerjee, Musfiqua,Naesens, Lieve
-
supporting information
p. 139 - 142
(2016/12/27)
-
- Clean and one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thione derivatives using maleic acid as an efficient and environmentally benign natural di-functional Br?nsted acid catalyst under solvent-free conditions
-
An efficient synthesis of Biginelli-type compounds using maleic acid as an economical di-functional Br?nsted acid catalyst in a one-pot, three-component reaction of β-ketoesters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) a
- Maghsoodlou, Malek Taher,Heydari, Reza,Lashkari, Mojtaba,Mohamadpour, Farzaneh
-
p. 160 - 164
(2019/06/24)
-
- Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition
-
A novel and green approach was adopted for the synthesis of 3,4-dihydropyrimidin-2(1H)-one/thiones derivatives using Punica granatum peel as an inexpensive, efficient and mild catalyst under solvent-free condition. The methodology is characterized by high
- Mohammadian, Narges,Akhlaghinia, Batool
-
p. 3325 - 3347
(2017/04/21)
-
- Nanoparticles of organosilane-based NaHSO4 ionic liquid immobilized on silica as reusable heterogeneous catalyst for one-pot synthesis of 2-oxo-and thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidines
-
Background: In spite of the fact that there are numerous reagents and methods to synthesize the dihydropyrimidinones via Biginelli reaction, but excellent yields, shorter reaction time and easy work-up are important factors which are not usually found tog
- Abri, Abdolreza,Khojasteh, Mohsen Ghasemian
-
p. 172 - 180
(2017/06/21)
-
- Synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrimidinone derivatives using glutamic acid as an efficient catalyst
-
The efforts to use green catalysts for organic synthesis are undeniable. Natural catalysts are biodegradable and easy to access. Herein, glutamic acid was applied as a natural and green catalyst for the synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydro
- Khandan-Barani, Khatereh,Kangani, Mehrnoosh,Mirbaluchzehi, Maryam,Siroos, Zahra
-
p. 751 - 755
(2017/08/10)
-
- 1-Methyl-2-oxopyrrolidinium perchlorate ionic liquid in synthesis of 5-ethoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones
-
A multicomponent Biginelli reaction in a solvent-free conditions catalyzed by 1-methyl-2-oxopyrrolidinium perchlorate ionic liquid was studied. The сondensation of aromatic aldehydes, urea (thiourea), and acetoacetic ester yielded substituted 5-ethoxycarb
- Badalova,Abbasov,Valiyev,Alieva,Talybov
-
p. 2739 - 2743
(2017/12/26)
-
- Organosilane sulfonated graphene oxide in the Biginelli and Biginelli-like reactions
-
Organosilane sulfonated graphene oxides (SSi-GO) have been synthesized by a two-step procedure involving the grafting of graphene oxide (GO) using 3-chloropropyltriethoxysilane (CCPTES) and subsequent oxidation using sulfanilic acid. It has been shown tha
- Safari, Javad,Gandomi-Ravandi, Soheila,Ashiri, Samira
-
p. 512 - 520
(2016/01/12)
-
- Solid-Supported Synthesis of Flexible Dimeric Pyridinium Salts and Their Catalytic Activities
-
The synthesis of flexible dimeric pyridinium ionic liquids by both conventional and solid-supported approaches are described. We have optimized the Biginelli reaction with various concentrations of our synthesized ionic liquids with various counter ions.
- Manikandan, Chitrarasu,Ganesan, Kilivelu
-
supporting information
p. 1527 - 1530
(2016/06/14)
-
- Cu-EDTA-modified APTMS-Fe3O4@SiO2 core-shell nanocatalyst: A novel magnetic recoverable catalyst for the Biginelli reaction
-
A novel copper-ethylenediamine tetracarboxylate modified core-shell magnetic catalyst is introduced. The prepared catalyst was fully characterized by various spectroscopic analyses such as XRD, SEM, FT-IR, EDX, ICP, and CHNOS. After characterization, its
- Sheykhan, Mehdi,Yahyazadeh, Asieh,Rahemizadeh, Zahra
-
p. 34553 - 34563
(2016/05/09)
-
- 1,4-diazabicyclo[2.2.2]octanium diacetate: As a new, effective and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and-thiones
-
In this study, a new, effective and environmentally benign procedure for the synthesis of dihydropyrimidinone and thione derivatives with various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as a novel acidic ionic liquid, in high yield and short reaction time is reported. This method provides several advantages such as easy work-up, green, environmental friendliness and fast reaction condition along with high yields.
- Fekri, Leila Zare,Movaghari, Mahsa
-
p. 406 - 413
(2016/10/18)
-
- Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction
-
In this report, an efficient high-yield method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli reaction with various aldehydes, β-ketoesters/β-diketones and urea/thiourea is described. The reaction was catalyze
- Khatri, Chetan K.,Rekunge, Deelip S.,Chaturbhuj, Ganesh U.
-
supporting information
p. 10412 - 10417
(2016/12/07)
-
- New Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Benzotriazolium-Based Ionic Liquids under Solvent-Free Conditions
-
An efficient synthesis of novel 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) and their derivatives, using Br?nsted acidic ionic liquid [C2 O2 BBTA][TFA] as a catalyst, from the condensation of aryl aldehyde, β-ketoester and urea was described. Reactions procee
- Liu, Zhiqing,Ma, Rong,Cao, Dawei,Liu, Chenjiang
-
-
- Saccharin: a green, economical and efficient catalyst for the one-pot, multi-component synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole
-
Abstract: In this method, we have reported the catalytic ability of saccharin as a green, eco-friendly catalyst for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. This present methodology has notable benefits such as green, inexpensive and non-toxic catalyst, one-pot, environmental benign nature, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly. Graphical Abstract: We have studied the catalytic ability of saccharin as a green, economical and environmentally benign nature for the multi-component efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones derivatives, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives and substituted dihydro-2-oxypyrrole with excellent yields and short reaction times. Green catalyst, mild, non-toxic, inexpensive, simple operational procedures, one-pot, high catalytic activity, eco-friendly, easily separated from the reaction mixture with no column chromatographic for the one-pot multi-component synthesis of these compounds are the most important advantages of this procedure.[Figure not available: see fulltext.]
- Mohamadpour, Farzaneh,Maghsoodlou, Malek Taher,Heydari, Reza,Lashkari, Mojtaba
-
p. 1549 - 1560
(2016/07/06)
-
- One-pot three-component Biginelli-type reaction to synthesize 3,4-dihydropyrimidine-2-(1H)-ones catalyzed by Co phthalocyanines: Synthesis, characterization, aggregation behavior and antibacterial activity
-
The synthesis of a novel phthalonitrile derivative with pyridine-2-thiol and 2,4,6-trimethylphenylamine substituents functionalized groups and its peripherally tetrasubstituted cobalt phthalocyanine and cationic phthalocyanines complexes were reported. Th
- Medyouni, Rawdha,Elgabsi, Wissal,Naouali, Olfa,Romerosa, Antonio,Sulaiman Alayed, Abdullah,Baklouti, Lasaad,Hamdi, Naceur
-
p. 165 - 174
(2016/07/06)
-
- Air-stable Organobismuth(V) Bisperfluorooctanesulfonate as an Efficient Catalyst for the Synthesis of N-Containing Compounds
-
Triphenyl bismuth bisperfluorooctanesulfonate is an air- and water-stable Lewis acid. It exhibits high catalytic efficiency for the synthesis of nitrogen heterocycles such as diindolylmethane derivatives, dihydropyrimidinones, dihydropyridines and 1,2-disubstitued benzimidazoles under mild condition. Furthermore, it can be reused without loss of activity in a test of five cycles.This catalytic system affords a simple and efficient way for the synthesis of N-containing compounds.
- Wang, Penghui,Wang, Jinying,Au, Chak-Tong,Qiu, Renhua,Xu, Xinhua,Yin, Shuang-Feng
-
supporting information
p. 1302 - 1308
(2016/04/26)
-
- A unique opportunity for the utilization of glass wastes as a resource for catalytic applications: toward a cleaner environment
-
Although glass recycling has been conducted since 1970s, and even though recycled glass waste has been used in the construction of various alternative products, the utilization of glass waste for catalytic applications has not been fully considered until
- Zolfagharinia, Somayeh,Koukabi, Nadiya,Kolvari, Eskandar
-
p. 113844 - 113858
(2016/12/24)
-
- An efficient synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and thiones catalyzed by a novel br?nsted acidic ionic liquid under solvent-free conditions
-
We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Br?nsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli rea
- Zhang, Yonghong,Wang, Bin,Zhang, Xiaomei,Huang, Jianbin,Liu, Chenjiang
-
p. 3811 - 3820
(2016/08/31)
-
- Air-stable zirconocene bis(perfluorobutanesulfonate) as a highly efficient catalyst for synthesis of N-heterocyclic compounds
-
Zirconocene bis(perfluorobutanesulfonate) is air- and water-stable and proved to be ionic on basis of conductivity measurements. It exhibits high catalytic efficiency for the synthesis of N-heterocyclic compounds under solvent-free condition, such as benzimidazoles, benzodiazepines, dihydropyrimidinones and dihydropyridines under mild condition. Furthermore, it can be reused without loss of activity in a test of five cycles. This catalytic system affords a simple and efficient approach for the synthesis of N-heterocyclic compounds.
- Wang, Jinying,Li, Ningbo,Qiu, Renhua,Zhang, Xiaohong,Xu, Xinhua,Yin, Shuang-Feng
-
-
- β-Cyclodextrin-propyl sulfonic acid: A new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidones via Biginelli reaction
-
β-Cyclodextrin-propyl sulfonic acid (β-CD-PSA) is reported as a new and eco-friendly catalyst for the synthesis of 3,4-dihydropyrimidinones from one-pot multi-component reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under so
- Gong, Kai,Wang, Hualan,Wang, Shuxin,Ren, Xiaoxue
-
p. 4830 - 4834
(2015/07/27)
-
- Novel one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8-tetrahydroquinazoline-2,5-diones using pyridinium p-toluenesufonate as catalyst
-
A mild, simple and efficient procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8-tetrahydroquinazoline-2,5-diones is described using pyridinium p-toluenesufonate as an efficient catalyst under mild conditions. Simple methodologies
- Khodja, Imène Amine,Boulcina, Raouf,Debache, Abdelmadjid
-
-
- Carbon nanotubes supported by titanium dioxide nanoparticles as recyclable and green catalyst for mild synthesis of dihydropyrimidinones/thiones
-
The catalytic activity of titanium dioxide supported on carbon nanotubes has been investigated in a one-pot three components condensation reaction (Biginelli reaction). The TiO2-CNT nanocomposites as catalyst are highly stable and completely he
- Safari, Javad,Gandomi-Ravandi, Soheila
-
p. 241 - 247
(2014/05/06)
-
- Titanium dioxide supported on MWCNTs as an eco-friendly catalyst in the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones accelerated under microwave irradiation
-
Some transition metal oxides supported on MWCNTs were prepared as novel heterogeneous catalysts using the facile processes. Then, the catalytic behaviour of transition metal oxide-MWCNT nanocomposites was investigated in the Biginelli one-pot cyclocondens
- Safari, Javad,Gandomi-Ravandi, Soheila
-
p. 3514 - 3521
(2014/08/05)
-
- Propylphosphonic anhydride-catalyzed tandem approach for biginelli reaction starting from alcohols
-
An efficient and highly convergent route to dihydropyrimidinones (DHPMs) has been developed by one-pot threecomponent oxidative cyclocondensation of a variety of alcohols, β-ketoesters/β-oxodithioester and urea in the presence of T3Pμ/ DMSO. This new appr
- Revanna, Cigalli N.,Raghavendra, Goravanalli M.,Vijay, T. A. Jenifer,Rangappa, Kanchugarakoppal S.,Badregowda, Doddamedur G.,Mantelingu, Kempegowda
-
supporting information
p. 178 - 180
(2014/03/21)
-
- Structure based virtual screening-driven identification of monastrol as a potent urease inhibitor
-
Virtual screening uses computer based methods to discover new ligands on the basis of biological structures. Among all virtual screening methods structure based docking has received considerable attention. In an attempt to identify new ligands as urease i
- Rashid, Umer,Batool, Iram,Wadood, Abdul,Khan, Ajmal,Ul-Haq, Zaheer,Chaudhary, Muhammad Iqbal,Ansari, Farzana Latif
-
-
- A green synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives using nanosilica-supported tin(II) chloride as a heterogeneous nanocatalyst
-
Efficient, green, and straightforward synthesis of 3,4-dihydropyrimidine- 2(1H)-one/thione derivatives under favorable conditions has been achieved by reaction of urea/thiourea, aldehydes, and ethyl acetoacetate, using the synthetic potential of nanosilic
- Safaei Ghomi, Javad,Teymuri, Raheleh,Ziarati, Abolfazl
-
p. 1865 - 1870
(2014/01/06)
-
- Synthesis of novel benzothiazolium ionic liquids and their catalytic performance in biginelli reaction
-
Two new ionic liquids based on benzothiazolium cation were synthesized in satisfactory yields by using a modified two-step one-pot method. Then these ionic liquids were used as effective and environmentally friendly catalysts for the synthesis of 3,4-dihy
- Liu, Jiabing,Song, Hang,Luo, Wenfeng,Hui, Liwei,Yao, Shun
-
p. 431 - 436
(2013/07/27)
-
- DABCO as a mild and efficient catalyst for the synthesis of tetrahydropyrimidines
-
Tetrahydropyrimidine derivatives have been synthesized in good to high yields through an efficient and one-pot condensation reaction of aldehydes, ethyl acetoacetate and urea (thiourea) using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an inexpensive, eco-fr
- Foroughifar, Naser,Mobinikhaledi, Akbar,Rabeie, Bahare,Jalili, Leila
-
p. 491 - 495
(2014/04/03)
-
- Biocatalysts for multicomponent Biginelli reaction: Bovine serum albumin triggered waste-free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones
-
Bovine serum albumin (BSA) promoted simple and efficient one-pot procedure was developed for the direct synthesis of 3,4-dihydropyrimidin-2(1H)-ones including potent mitotic kinesin Eg5 inhibitor monastrol under mild reaction conditions. The catalyst recy
- Sharma, Upendra K.,Sharma, Nandini,Kumar, Rajesh,Sinha, Arun K.
-
p. 1031 - 1037
(2013/07/05)
-
- Trifluoroethanol as a metal-free, homogeneous, and recyclable medium for the efficient one-pot synthesis of dihydropyrimidones
-
Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of b-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not re
- Rashmi,Sandhya,Raghava,Kumara,Mantelingu,Rangappa
-
experimental part
p. 424 - 433
(2011/11/29)
-
- 22% Co/CeO2-ZrO2-catalyzed synthesis of 1,2,3,4-tetrahydro-2-pyrimidinones and -thiones
-
Three-component condensation reaction of an aldehyde with β-ketoester and urea or thiourea in acetonitrile to afford the dihydropyrimidinones and thions (DHPMs) in the presence of 22% Co/CeO2-ZrO2 nano fine particle as a novel, reusable and green catalyst is reported. Utilizing of 22% Co/CeO2-ZrO2 nano fine particle catalyst also offers a cleaner process in that it can be reused and will not bring additional pollutants into the "environment" that is agreeable green chemistry point of view.
- Biklarian, Hajar,Behbahani, Farahnaz K.,Fakhroueian, Zahra
-
p. 580 - 584
(2012/11/13)
-
- Polyvinylsulfonic acid: An efficient, water-soluble and reusable bronsted acid catalyst for the three-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones in water and ethanol
-
A facile and environmentally benign protocol has been developed for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones from the cyclocondensation reaction of aldehyde, ethyl acetoacetate (β-dicarbonyl compound) and urea or th
- Rahmatpour, Ali
-
p. 1505 - 1511
(2013/08/25)
-
- Monolayer-protected silver nanoparticles: An efficient and versatile reagent for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones (thiones)
-
Silver nanoparticles has been prepared and shown to efficiently catalyse the one-pot, three-component reaction of an aromatic aldehyde, urea or thiourea and a 1,3-diketone at reflux, to afford the corresponding 3,4-dihydropyrimidine- 2-(1H)-ones in high y
- Sadeghi, Bahareh,Zavar, Salehe,Hassanabadi, Alireza
-
experimental part
p. 343 - 346
(2012/09/22)
-
- Bronsted acidic ionic liquid-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1h)-ones and thiones under solvent-free conditions
-
An efficient and convenient procedure for the synthesis of 3,4-dihydropyrimidin- 2(1H)-ones and thiones by condensation of ethylacetoacetate, aldehydes, and urea or thiourea in the presence of methylimidazolium hydrogensulfate is described. Aromatic and a
- Hajipour, Abdol R.,Khazdooz, Leila,Zarei, Amin
-
experimental part
p. 2200 - 2208
(2011/06/27)
-
- One-pot synthesis of dihydropyrimidiones via environmentally friendly enzyme-catalyzed Biginelli reaction
-
A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in go
- Li, Wanmei,Zhou, Guobin,Zhang, Pengfei,Lai, Yifeng,Xu, Shifu
-
experimental part
p. 2067 - 2077
(2011/10/13)
-